紫红獐牙菜口山酮及环烯醚萜类化合物的研究  

Xanthonoids and Iridoid Glycosides from Swertia punicea Hemsl.

作　　者：田峦鸢[1] 陈家春[1] 白雪[1] 方进波[1] 

机构地区：[1]华中科技大学同济医学院药学院天然药物化学与资源评价湖北重点实验室,武汉430030

出　　处：《天然产物研究与开发》2010年第6期979-983,共5页Natural Product Research and Development

基　　金：国家自然科学基金(30271590)

摘　　要：采用各种柱色谱法对紫红獐牙菜的石油醚和正丁醇部位进行分离纯化,从石油醚部位分离鉴定得到6个化合物,利用理化性质和波谱学方法分别鉴定为oleanolic acid(1),swerchirin(2),sweriaperenine(3),bellidifo-lin(4),gentiacaulein(5)和1,7,8-trihydroxy-3-methoxyxanthone(6);从正丁醇部位分离鉴定得到9个化合物,分别鉴定为8-[(β-D-glucopyranosyl)oxy]-1,5-dihydroxy-3-methoxyxanthone(7),5-[(β-D-glucopyranosyl)oxy]-1,8-di-hydroxy-3-methoxyxanthone(8),7-[(β-D-xylopyranosyl)oxy]-1,8-dihydroxy-3-methoxyxanthone(9),8-[(β-D-gluco-pyranosyl)oxy]-1,3,5-trimethoxyxanthone(10),swertiamarin(11),tetrahydrosertianolin(12),8-hydroxy-10-hydro-sweroside(13),campestroside(14)以及uridine(15)。其中,化合物15首次从该属植物中得到,化合物9、10、12和13首次从该植物中分离得到。The chemical constituents of Swertia punicea Hemsl.were isolated by various column chromatographic methods.Fifteen compounds were obtained and identified as oleanolic acid（1）,swerchirin（2）,sweriaperenine（3）,bellidifolin（4）,gentiacaulein（5）,isobellidifolin（6）,8-[（β-D-glucopyranosyl）oxy]-1,5-dihydroxy-3-methoxyxanthone（7）,5-[（β-D-glucopyranosyl）oxy]-1,8-dihydroxy-3-methoxyxanthone（8）,7-[（β-D-xylopyranosyl）oxy]-1,8-dihydroxy-3-methoxyxanthone（9）,8-[（β-D-glucopyranosyl）oxy]-1,3,5-trimethoxyxanthone（10）,swertiamarin（11）,tetrahydrosertianolin（12）,8-hydroxy-10-hydrosweroside（13）,campestroside（14）,and uridine（15）.Compounds 15 were isolated from this genus and 9,10,12,13 were obtained from this plant for the first time.

关 键 词：紫红獐牙菜 石油醚部位 正丁醇部位 口山酮 烯醚萜 

分 类 号：R284.1[医药卫生—中药学] Q946.91[医药卫生—中医学]