胰岛素抵抗与亚临床甲状腺功能减退症的相关性  

Study on insulin resistance in patients with subclinical hypothyroidism

作　　者：葛余浩[1] 汪琰[1] 张薇薇[1] 王璇[1] 

机构地区：[1]安徽医科大学附属省立医院安徽省立医院干部病房,合肥230001

出　　处：《中国临床保健杂志》2010年第6期594-595,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨胰岛素抵抗与亚临床甲状腺功能减退症的相关性。方法选择37例甲状腺功能减退患者和38例甲状腺功能正常受试者,依据其空腹FT3,FT4,TSH水平分为3组:健康对照组38例、临床甲状腺功能减退组(甲减组)19例、亚临床甲状腺功能减退组(亚甲减组)18例。均给予口服葡萄糖耐量试验,检测其空腹及餐后2h血糖和胰岛素浓度。分别计算稳态模式胰岛素抵抗指数(HOMA-IR)及胰岛素敏感性指数(ISI-Matsuda)。结果和对照组相比,亚甲减组、甲减组空腹和餐后2h血胰岛素浓度均升高(P<0.05);亚甲减组和甲减组HOMA-IR比对照组升高(P<0.05);亚甲减组、甲减组ISI-Matsuda比对照组降低(P<0.01)。结论亚临床甲状腺功能减退症和甲状腺功能减退症存在胰岛素抵抗,监测或治疗此类患者可以降低胰岛素抵抗及其相关疾病的风险。Objective To investigate the relationship between insulin resistance and subclinical hypothyroidism（SHO）.Methods 75 patients were included in this study,and we assessed the sensitivity of glucose metabolism to insulin by an oral glucose tolerance test in 38 euthyroid subjects（EU）,19 patients with clinical hypothyroidism（HO）,and 18 patients with SHO.Results The patient with SHO and HO had higher plasma insulin than the EU,P〈0.05.Homeostasis model assessment index was increased in patient with SHO and HO compared with patients with EU（P〈0.05）,while Matsuda index decreased in SHO and HO versus EU（P〈0.01）.Conclusion There exits similar insulin resistance in the patients with SHO and those with HO.Monitoring and treatment may decrease the risk for insulin resistance-associated disorders in the patients with SHO or HO.

关 键 词：甲状腺功能减退症 胰岛素抵抗 危险因素 

分 类 号：R581.2[医药卫生—内分泌]