动脉外膜交感神经网剥脱切除术后肢体骨内压、血液流变学、神经肽改变的实验研究  

Experimental study on the change in limb intraosseous pressure,blood viscosity and neuropeptide after the excision of sympathetic plexus in arterial adventitia

作　　者：吴珊鹏[1] 林欣[2] 

机构地区：[1]福建医科大学附属泉州市第一医院骨科,福建泉州362000 [2]首都医科大学附属北京天坛医院骨科,北京100050

出　　处：《中国医药导报》2010年第36期21-22,共2页China Medical Herald

基　　金：中国博士后科学基金(No.20080430443);福建省自然科学基金(No.2007J0299);福建省医学创新课题(No.2007-CX-20);福建省泉州市科技项目基金(No.2007223);福建省泉州市优秀人才培养专项经费

摘　　要：目的:探讨交感神经与骨内压的关系。方法:将15只新西兰纯种大白兔制作成右胫骨上端骨内高压模型,测量胫骨上端骨内压、血液流变学、神经肽Y(NPY)和降钙素基因相关肽(CGRP),然后将15只大白兔行右股动脉外膜交感神经网剥脱切除术,再测量术后上述各项指标。结果:术后骨内压和骨髓内血液黏度下降,CGRP增加,NPY含量下降。结论:交感神经切断后,骨髓内血液稀释、黏度下降、血管扩张,骨内压有下降趋势。Objective： To explore the relationship between sympathetic nerves and intraosseous pressure.Methods： The model of intraosseous hypertension in upper tibia was established in 15 experimental rabbits.The intraossseous pressure,hemorrheology and neuropeptide were measured.Then the sympathetic plexus of arteria femoralis was excised,After the operation,these indicators were measured again.Results： Intraosseous pressure and intramedullary blood viscosity decreased,CGRP increased,and NPY level decreased after the operation.Conclusion： After the excision of sympathetic nerves,intramedullary blood diluted,blood viscosity decreased,blood vessel dilated,and intraosseous pressure tended to decrease.

关 键 词：交感神经 骨内压 血液流变学 神经肽 

分 类 号：R651[医药卫生—外科学]