FK506拮抗庆大霉素耳毒性的实验观察  

FK506 as antagonist to ototoxicity of Gentamycin

作　　者：王晓[1] 鞠宏霜[2] 梁桂玲[1] 闫永红[1] 苏梅[1] 

机构地区：[1]山东大学齐鲁医院耳鼻咽喉科,济南250012 [2]山东大学齐鲁医院桓台分院耳鼻咽喉科,山东桓台256400

出　　处：《山东大学耳鼻喉眼学报》2010年第6期13-16,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的初步探讨FK506拮抗庆大霉素耳毒性的效果。方法通过分别检测庆大霉素损伤组与庆大霉素加不同剂量FK506(1mg、2mg)保护组实验动物听性脑干反应(ABR)阈值的变化,并结合耳蜗铺片琥珀酸脱氢酶(SDH)染色方法观察动物耳蜗形态学变化,观察FK506拮抗庆大霉素耳毒性的作用。结果实验动物的听觉生理检查显示FK506能够拮抗庆大霉素耳毒性,FK506保护组动物听阈明显低于庆大霉素损伤组(P<0.01),随剂量增加,保护作用越明显;同时形态结果显示FK506保护组外毛细胞缺失明显少于庆大霉素损伤组(P<0.01)。结论 FK506对庆大霉素引起的耳毒性有拮抗作用。Objective To investigate the effects of FK506 to antagonize ototoxicity of Gentamycin. Methods The gentamycin group and the groups of gentamycin plus different doses of FK506 （1 mg,2 mg） were set up. Then,the auditory brainstem response （ABR） threshold was measured to explore the changes in hearing function. Cochlear preparations were stained with SDH to observe morphological changes. Results Auditory data and morphological changes demonstrated significant differences between the gentamycin group and the groups of FK506 （P0.05）. FK506 could reduce the damages of gentamycin in the cochlea. Conclusion Based on the experiment,FK506 can relieve the ototoxicity induced by gentamycin.

关 键 词：耳毒性 FK506 庆大霉素 

分 类 号：R978.12[医药卫生—药品]