Labrasol对葛根素角膜透过性的研究  

Investigation of Labrasol on the corneal permeability of puerarin in vitro

作　　者：舒乐新[1] 赵启铎[2] 刘志东[1] 李琳[1] 宋西卫[1] 李楠[1] 

机构地区：[1]天津中医药大学现代中药发现与制剂技术教育部工程研究中心,研究生天津300193 [2]天津中医药大学,天津300193

出　　处：《天津中医药》2010年第6期506-508,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：国际科技合作项目(2007DFC31670)

摘　　要：[目的]研究Labrasol对葛根素角膜透过性的影响。[方法]采用体外扩散实验考察不同浓度的Labrasol对葛根素角膜透过性的影响。[结果]Labrasol质量浓度为0.5%、1%、1.5%、2%、3%时,葛根素的表观渗透系数分别是对照组的1.87倍、4.41倍、7.42倍、8.02倍和9.60倍,与对照组比都有显著性差异(P<0.01)。[结论]质量浓度为0.5%～3%的Labrasol均能显著性的增加葛根素的表观渗透系数,且对角膜无刺激性。[Objective]To explore the use of Labrasol in an ocular drug delivery system.[Methods]The effects of Labrasol on the cornealpermeability of puerarin were investigated in vitro,using isolated rabbit corneas.[Results]The 0.5%,1%,1.5%,2%,3% Labrasol showedincrement as much as 1.87,4.41,7.42,8.02 and 9.60 times in the apparent permeability of puerarin,respectively compared with the onesin the control（P0.01）.[Conclustion] The 0.5%～3% Labrasol can enhance the corneal apparent permeability of puerarin significantlyand is not irritant to eye tissues.

关 键 词：辛酸癸酸聚乙二醇甘油酯 葛根素 角膜透过性 

分 类 号：R282.71[医药卫生—中药学]