硫化氢中毒机制及治疗研究进展  

Research progress on mechanism and treatment of hydrogen sulfide poisoning

作　　者：吴娜[1] 王涤新[1] 

机构地区：[1]首都医科大学附属北京朝阳医院职业病与中毒医学科,北京100020

出　　处：《中国工业医学杂志》2010年第6期434-436,共3页Chinese Journal of Industrial Medicine

基　　金：科技部卫生行业科研专项项目资助(200802020)

摘　　要：硫化氢除了主要抑制细胞色素氧化酶外,还有抑制单胺氧化酶、诱导产生自由基损伤等多种毒性机制。治疗硫化氢中毒主要是及早给予氧疗,高压氧治疗急性缺血缺氧性脑病宜早期和适当。研究显示羟钴胺素对硫化氢中毒有解毒作用。The toxic mechanism of hydrogen sulfide（H2S） is not only inhibiting cytochrome oxidase but also inhibitingmonoamine oxidase and generating free radicals etc..Therefore,oxygen therapy should be very important and given as soon aspossible for H2S poisoning;hyperbaric oxygen therapy for acute hypoxic ischemic brain damage is reasonable and should also begiven early and appropriately.Additionally,evidences showed,that hydroxocobalamin（vitamin B12a） could work as an anti-dote against H2S poisoning as well.

关 键 词：硫化氢中毒 自由基 高压氧 羟钴胺素 

分 类 号：R135.14[医药卫生—劳动卫生]