259例HBV持续感染患者血清ANA、抗ss-DNA和RF表达测定及分析  

Determination and analysis of serum ANA,anti-ss-DNA and RF expression in 259 patients with persistent infection of HBV

作　　者：董振芳[1] 亓琳[1] 焦玉莲[1] 张炳昌[1] 

机构地区：[1]山东大学附属省立医院,济南250021

出　　处：《山东医药》2010年第51期10-11,共2页Shandong Medical Journal

基　　金：山东省自然科学基金资助项目(Y2008C134;ZR2009CM139)

摘　　要：目的探讨HBV持续感染对机体自身抗体谱的影响。方法用ELISA法检测259例HBV持续感染患者(观察组)和260例健康体检者(对照组)血清抗核抗体(ANA)、抗单链DNA(抗ss-DNA)和类风湿因子(RF)水平。结果观察组血清抗ss-DNA、ANA、RF阳性率均显著高于对照组(P均<0.05),但HBV-DNA阳性与阴性者比较无显著差异。结论 HBV持续感染可使机体自身抗体谱发生变化,此为进一步研究自身抗体在病毒性乙型肝炎发展和转归中的作用及病毒性乙型肝炎患者的自身免疫启动机制奠定了基础。Objective To investigate the influence of HBV persistent infection on autoantibody profile.Methods ELISA method was employed for ANA,anti-ss-DNA and RF from serum of 259 HBV persistent infections（observed group）and 260 healthy donors（control group）.Results The positive rate of ANA,RF and anti-ss-DNA in observed group were significantly higher than those in control group（all P0.05）,but no distinct difference were found between HBV-DNA positive group and HBV-DN A negative group.Conclusions The changement of autoantibody profile is associat ed with HBV persistent infection.It provide the foundation for further study of the effect of autoantibody to viral hepatitis type B development and final outc ome and the trigger mechanism of autoimmunity for viral hepatitis type B patient s.

关 键 词：乙型肝炎病毒 自身抗体 抗单链DNA 抗核抗体 类风湿因子 

分 类 号：R512.62[医药卫生—内科学]