非甾体抗炎新药联苯乙酸的合成  

Synthesis of Nonsteroidal Antiinflammatory Drug Felblinac

作　　者：陈勇[1] 刘振中[1] 刘宏民[1] 陈恒昌[1] 刘玉坤[1] 

机构地区：[1]郑州大学,郑州450052

出　　处：《郑州大学学报（自然科学版）》1999年第3期76-78,共3页Journal of Zhengzhou University (Natural Science)

摘　　要：以苯乙腈为起始原料，经四步反应合成非甾体抗炎新药联苯乙酸．通过对各步反应进行研究，找到了理想反应条件，四步反应总收率２７ ．６ ％ ．A new synthetic route for preparation felblinac via four steps from phenylacetonitrile as starting material was developed.Good reaction conditions were found by studying each step of this synthesis route. The overall yied of flebinac from phenylacetonitrile was 27.6% in four steps.

关 键 词：联苯乙酸 非甾体抗炎药 合成 苯乙腈 

分 类 号：TQ463.4[化学工程—制药化工]