双水平气道正压通气对冠心病并慢性心力衰竭患者血脂的影响  被引量:2

The influence of Bi-Level Positive Airway Pressure ventilation on lipid level in patients with chronic heart failure of coronary heart disease

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作  者:张春云[1] 陈益民[1] 

机构地区:[1]广州医学院港湾医院呼吸内科,广东省广州510700

出  处:《中国基层医药》2010年第1期48-49,共2页Chinese Journal of Primary Medicine and Pharmacy

摘  要:目的探讨双水平气道正压通气(BiPAP)治疗对冠心病并慢性心力衰竭患者血脂水平的影响。方法对20例冠心病合并慢性心力衰竭患者经BiPAP治疗前及治疗后(4周、12周)进行血脂水平检测与比较。结果冠心病并慢性心力衰竭患者观察组治疗前血清总胆固醇(TC)(7.47±0.12)mmol/L、甘油三酯(TG)(3.52±0.13)mmol/L、低密度脂蛋白胆固醇(LDLc)(3.73±0.11)mmol/L、载脂蛋白-B(Apo-B)(1.37±0.02)g/L明显低于治疗后14周[TC(4.5±0.03)mmol/L,TG(2.6±0.02)mmol/L,LDLc(2.8±0.06)mmol/L,Apo—B(1.02±0.02)g/L)(t=2.154,t=2.278,t=2.311,t=2.347,P均〈0.05)];观察组治疗后14周HDLc(1.45±0.02)mmol/L,Apo—A(1.21±0.03)g/L,低于治疗前[HDLc(1.05±0.01)mmol/L、Apo—A(0.87±0.01)g/L)(t=2.234,t=2.318,P均〈0.05)]。结论冠心病并慢性心力衰竭患者长期BiPAP治疗可以有效改善其脂质代谢。Objective To study the influence of BiPAP on lipid level in patients with chronic heart failure of coronary heart disease. Methods 20 patients with chronic heart failure of coronary heart disease were taken BiPAP: Blood samples were taken from forearm vein before and 4 weeks and 12 weeks after treatment, the lipid level was measured and compared. Results The observation group of The coronary heart disease with chronic heart failure in pre-treatment serum level of total cholesterol( TC ) (7.47 ± 0. 12 ) mmol/L, triglycerides (TG) ( 3.52 ±0. 13 ) retool/L, low-density lipoprotein cholesterol ( LDLc ) ( 3. 73 ±0. 11 ) nmmol/L, apolipoprotein-B ( Apo-B ) ( 1.37 ±0. 02 ) g/L were significantly lower than 14 weeks after treatment TC ( 4. 5 ±0. 03 ) retool/L, TG ( 2. 6 ±0. 02 ) mmol/L, LDLc (2. 8 ±0. 06) mmol/L,Apo-B( 1.02 ± 0. 02) g/L) (t =2. 154,t =2. 278,t =2. 311 ,t =2. 347,P all 〈0. 05) in coronary heart disease with chronic heart failure;The observation group after treatment 14 weeks of HDL-CH( 1.45± 0. 02) mmol/Land Apo-A( 1.21 ±0. 03 ) g/L lower than before treatment HDLc ( 1.05 ± 0.01 ) mmol/L, Apo-A ( 0. 87 ±0. 01 ) g/L( t = 2.23g/L, t = 2. 318, P all 〈 0. 05 ) in coronary heart disease with chronic heart failure. Conclusion Bi-PAP therapy could effectively to ameliorate lipid metabolism in patients with chronic heart failure of coronary heart disease in the long term.

关 键 词:无创正压通气 冠状动脉疾病 心力衰竭 血脂 

分 类 号:R541[医药卫生—心血管疾病]

 

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