肺炎克雷伯菌、大肠埃希菌耐药性变迁分析  

The Trends of Antibiotic Resistance of Klebsiella pneumoniae and Escherichia coli Analysis

作　　者：毛立群[1] 张添威 张松[1] 

机构地区：[1]台州市第一人民医院呼吸内科,浙江省台州318020

出　　处：《中国基层医药》2010年第1期54-55,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的了解临床分离肺炎克雷伯菌、大肠埃希菌对抗生素耐药性变迁。方法采用VITEK-32微生物全自动分析系统进行细菌鉴定和药敏检测。结果4年中肺炎克雷伯菌、大肠埃希菌超广谱β-内酰胺酶（ESBLs）的发生率呈逐年上升的趋势。2005年至2008年肺炎克雷伯菌、大肠埃希菌ESBLs菌发生率分别为36．6％、40．6％、41．5％、41．0％；产ESBLs菌对三代头孢、氨基糖苷类、喹诺酮类和磺胺类交叉耐药，且呈逐年上升趋势。结论肺炎克雷伯菌、大肠埃希菌的发生率呈逐年上升趋势，耐药率升高，临床应及时了解它们的耐药特点和变化，合理使用抗生素，有效控制ESBLs的传播。Objective To study the trend of antimicrobial resistance to clinical isolates of Klebsiella pneumoniae and Escherichia coli. Methods VITEK-32 automated analysis system was used for bacteria differentiation and drug resistance determination. Results TS From 2005 to 2008, the prevalence of ESBLs in isolates of K. pneumoniae and E. coli were increasing, their were 36. 6% ,40. 6% ,41.5% ,41.0% each year separately. The ESBLs-producing bacteria, multiple-drug-resistant to the third generation cephalosporin, aminoglycosides, quinolones and sulfonamides were also increased. Conclusion There is an increasing trend of ESBLs produces and resistences in K. pneu moniae and E. coli, It is important for clinical physicians to understand the distribution and the resistance characteristics of ESBLs producing K. pneumoniae and E. coli were to antibiotics, and to control the ESBLs spread.

关 键 词：肺炎克雷伯菌 大肠埃希菌 耐药性 Β-内酰胺酶类 

分 类 号：R446[医药卫生—诊断学]