调脉饮拆方抗心律失常作用的研究  

Study on Effect of Tiaomaiyin Separate Components on Experimental Arrhythmia

作　　者：解欣然[1] 易京红[2] 王军[3] 何薇[1] 张知非[3] 李静[2] 

机构地区：[1]北京市中医研究所,北京100010 [2]首都医科大学附属北京中医医院,北京100010 [3]首都医科大学基础医学院,北京100054

出　　处：《中国实验方剂学杂志》2011年第2期109-112,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：首都医科大学基础-临床合作项目(2007JL61)

摘　　要：目的:观察调脉饮全方及拆方对3种实验性心律失常动物模型的影响。方法:将动物随机分为模型组、调脉饮全方组、凉血清热主药功效组、益气养心辅药功效组、行气通脉辅药功效组和阳性药普罗帕酮组。通过记录Ⅱ导心电图,观察调脉饮全方及拆方对乌头碱诱发大鼠室性心律失常、哇巴因诱发豚鼠室性心律失常、结扎冠状动脉诱发大鼠心律失常3个实验性心律失常模型的作用。结果:调脉饮全方组与凉血清热组对乌头碱致大鼠心律失常、哇巴因诱发豚鼠室性心律失和结扎冠状动脉诱发大鼠心律失常发生率具有抑制作用。结论:调脉饮全方组与凉血清热组具有对抗实验性心律失常的作用。Objective：To observe influence of Tiaomaiyin drug and its separate components on three kinds of experimental arrhythmia in animals.Method：The animals were randomly divided into a model group,a group treated by whole Tiaomaiyin,a group treated by main components for Liangxue Qingre function,a group treated by assisted components for Yiqi Yangxin function,a group treated by assisted components for Xingqi Tongmai function and a group treated by a known effective drug（Propafenone）.By recording ECG,the effects of Tiaomaiyin and its separate components on ventricular arrhythmia induced by Aconitine in rats,that induced by Ouabain in guinea pigs,and that induced by ligating coronary artery were observed.Result： The whole Tiaomaiyin drug and the components for liangxueqingre function inhibited all the three kinds of ventricular arrhythmia in the three kinds of animals,respectively.Conclusion： The whole Tiaomaiyin drug and the components for Liangxue Qingre action provide the function against experimental arrhythmias.

关 键 词：调脉饮 拆方研究 实验性心律失常 凉血清热 

分 类 号：R285.5[医药卫生—中药学]