黄金菊药效组分解热的生物效应  

Biological Effects on Active Antipyretic Components Alignment of Huangjinju

作　　者：郑璐璐[1] 张贵君[1] 张春晖[1] 王晶娟[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国实验方剂学杂志》2011年第2期196-198,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省教育部产学研项目(03032)

摘　　要：目的:验证和进一步确定黄金菊解热的药效组分,为建立与其临床疗效对应的质量标准提供科学依据。方法:在HPLC分析法确定初步药效组分基础上,采用大鼠的酵母致热实验,对发热模型进行连续10 h的体温检测,设立了黄金菊水煎剂组、药效组分的低中高剂量组、阳性组与模型组进行比较,同时选用同类病症常用药双黄连口服液进行同步对照。结果:空白组与模型组相比,统计学差异显著(P<0.01),用药各组与模型组相比,差异有统计学意义(P<0.05),黄金菊的低、中、高药效组分组的大鼠体温在2～6 h的发热期内均低于模型组体温,具有明显的解热作用。结论:黄金菊的药效组分(黄芩苷、绿原酸、荭草苷和牡荆苷)可以作为黄金菊的解热药效组分。Objective： To verify and further define the active components alignment of antipyretic and provide the scientific basis date for the clinical curative effect of quality standards on Huangjinju.Method：On the basis of determining the active components alignment by HPLC analysis about classic prescription,take the fever model rats were made by dry yeast and provide the model of the fever for 10 hours of temperature detection,and set up the Huangjinju decoction group and the active components alignment group（high,middle and low dose） and the Positive group to compare with the model group,while similar symptoms common drugs used to synchronize the control Shuanghuanglian oral.Result：Comparing with the model group,there was significant difference（P 0.01） among the control group and the treatment group（P 0.05）.the active components alignment（high,middle and low dose） groups when body temperature in rats 2-6 hours after treatment temperature were lower than the model group,with significant antipyretic effect.Conclusion： The active components alignment of Huangjinju（baicalin,Chlorogenic acid,orientin and vitexin） really have significant antipyretic effects,so they are the active components alignment of antipyretic on Huangjinju.

关 键 词：黄金菊 解热药效组分 干酵母致热模型 生物效应 

分 类 号：R283.6[医药卫生—中药学]