碱性离子液体催化含1,2,4-三唑葡萄糖苷的合成  

Synthesis of glucoside compounds containing 1,2,4-triazoleyl groups catalyzed by alkaline ionic liquid

作　　者：王俊岭[1] 高喜平[1] 

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471003

出　　处：《化学试剂》2011年第1期94-96,共3页Chemical Reagents

摘　　要：以碱性离子液体[Bmim]OH为溶剂和催化剂,4-氨基-5-(4-吡啶基)-2,4-二氢-1,2,4-三唑-3-硫酮与四乙酰溴代葡萄糖进行Kenigs-Knorr反应,以88%的产率制备了两种葡萄糖苷。产物结构经1HNMR、13CNMR和IR确证,产物均为β型异构体。结果表明,该方法条件温和、产率较高、立体选择性好。所使用的离子液体对环境友好,并可循环使用。Two glucoside compounds containing 1,2,4-triazoleyl groups were synthesized in 88% yield via the Kenigs-Knorr reaction of 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide with 4-amino-5-（pyridin-4-yl）-2,4-dihydro[1,2,4]——tri-azole-3-thione using alkaline ionic liquid [Bmim] OH as the dual solvent and catalyst.The target compounds were identified by ^1HNMR,^13CNMR and IR spectra.The 1HNMR spectra showed that these compounds were β-anomer.This method features mild reaction conditions,high product yield and high stereospectificity of products.The alkaline ionic liquid is environmentally friendly and can be reused in production process.

关 键 词：碱性离子液体 1 2 4-三唑 葡萄糖苷 合成 

分 类 号：O626.26[理学—有机化学]