不同辅料对通塞脉浸膏粉体物理性质及其微丸成型性的影响研究  

Effects of different excipients on properties of Tongsaimai mixture and pellet molding

作　　者：汪晶[1] 吕志阳[1] 吴晓燕[1] 狄留庆[1] 董宇[1] 蔡宝昌[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046

出　　处：《中国中药杂志》2011年第1期37-40,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30873401);国家科技部863计划项目(2003AA2Z3247);江苏省自然基金项目(BK2005150);江苏省"青蓝工程"科技创新团队支持计划[苏教师(2008)30号]

摘　　要：目的:初步探讨通塞脉浸膏与不同辅料混合物的物理性质与其微丸成型性的相关性。方法:通过测定不同处方混合物的内聚力、塑性指数及所成微丸粉体学性质,运用主客观赋权法及多元回归分析其相关性。结果:混合物的塑性指数对微丸成型起主要影响,在所考察范围内呈正相关,内聚力与微丸成型呈负相关。结论:混合物的物理性质能显著地影响微丸成型。Objective： To study preliminarily on the relationship between properties of the mixture composed of Tongsaimai extract and different excipients and pellet molding.Method： The multivariate regression analysis was used to investigate the correlation of different mixture and pellet molding by measuring the cohesion,liquid-plastic limit of mixture,and the powder properties of pellets.The weighted coefficients of the powder proerties were determined by analytic hierarchy process combined with criteria importance through intercriteria correlation.Result： The results showed that liquid-plastic limit seemed to be a major factor,which had positive correlation with pellet molding,while cohesion had negative correlation with pellet molding in the measured range.Conclusion： The physical properties of the mixture has marked influence on pellet molding.

关 键 词：通塞脉 物理性质 微丸 相关性 

分 类 号：TQ461[化学工程—制药化工]