聚焦超声治疗外阴白色病变前后神经生长因子和P物质的变化分析  

Effect on expression of NGF and SP in white lesions of vulvaby focused ultrasound

作　　者：祝青[1] 刁庆春[2] 

机构地区：[1]乐山职业技术学院,四川614000 [2]重庆市第一人民医院皮肤科,400011

出　　处：《重庆医学》2011年第2期127-128,F0003,共3页Chongqing medicine

摘　　要：目的探讨聚焦超声治疗外阴白色病变的机制。方法采用免疫组化SP法检测外阴白色病变患者超声治疗前、后外阴皮肤组织中神经生长因子(NGF)和P物质(SP)的表达。结果外阴白色病变患者皮损中NGF和SP表达较正常皮肤增强(P<0.05),超声治疗后,患者皮损中NGF和SP表达较治疗前降低(P<0.05)。结论 NGF和SP可能参与外阴白色病变的发病,影响NGF和SP分泌、表达可能是聚焦超声治疗外阴白色病变的机制之一。Objective To investigate the mechanism on white lesions of vulva treated by focused ultrasound.Methods Studied changes of NGF and SP protein in tissue of white lesions of vulva before and after focused ultrasound therapy by the immunohistochemical method.Results Both NGF and SP protein were higher in the white lesions of vulva skin than those in the normal skin（P0.05）.The NGF and SP protein were lower than those before focused ultrasound irradiation（P0.05）.Conclusion NGF and SP may play an important role in the pathogenesis of white lesions of vulva.Controlling the secretion and expression of NGF and SP may be one of the mechanisms of focused ultrasound treating white lesions of vulva.

关 键 词：治疗 聚焦超声 外阴白色病变 机制 

分 类 号：R711.72[医药卫生—妇产科学]