β-环糊精-小檗碱包合物表征分析*  

Preparation and Characterization of β-Cyclodextrin-Berberine Inclusion Compound

作　　者：雷敬卫[1] 武雪芬[1] 崔晓鸽[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《中医学报》2011年第1期59-61,共3页Acta Chinese Medicine

基　　金：河南省自然科学基金资助项目(编号:0611045900)

摘　　要：目的:制备β-环糊精-小檗碱包合物,研究该包合物的组成比。方法:通过包合物晶体的显微形态、差热分析及核磁共振氢谱对包合物进行确认和表征。结果:小檗碱分子两端质子的化学位移都发生了比较大的变化,提示小檗碱的两端分别可以被β-环糊精包合;不同的投料比(主客体1∶1和2∶1)得到结晶形态不同的两种包合物,提示β-环糊精-小檗碱有1∶1型和2∶1型两种类型。结论:1∶1投料时,生成1∶1型为主的包合物;2∶1投料时生成2∶1型为主的包合物;在1∶1和2∶1之间投料时,生成1∶1型和2∶1型兼有的混合型包合物。Objective： To prepare β-cyclodextrin-berberine inclusion compound,to study the ratio of its ingredients.Methods： To confirm and characterize the inclusion compound by observing microscopic characters,DTA,and 1H-NMR.Results： Chemical shifts of protons at double ends of berberine changed greatly,which indicates the double ends of berberine molecule can be included by β-cyclodextrin;Different ratio of ingredients（ratio of subject molecule and object molecule 1∶1 and 2∶1）produced two kinds of inclusion compound with different crystals,which indicates β-cyclodextrin-berberine has two forms（1∶1 and 2∶1）.Conclusion： The form of inclusion compound is in relation to the ratio of ingredients.

关 键 词：β-环糊精-小檗碱包合物 核磁共振 包合物表征 

分 类 号：R284.1[医药卫生—中药学]