N-[(4-溴-3,5-二氟)苯基]马来酰亚胺合成  

Synthesis of N-[(4-Bromo-3,5-difluorine)-phenyl]Maleimide

作　　者：李延勋[1] 姚新鼎[1] 徐丽[1] 雒廷亮[1] 刘国际[1] 

机构地区：[1]郑州大学化工与能源学院,河南郑州450001

出　　处：《精细化工》2011年第1期97-100,共4页Fine Chemicals

摘　　要：以马来酸酐和4-溴-3,5-二氟苯胺为原料,对甲苯磺酸为催化剂,甲苯/DMF为混合溶剂,采用溶剂共沸法,制备了N-[(4-溴-3,5-二氟)苯基]马来酰亚胺,用FTIR、1HNMR和13CNMR对产物进行了结构表征,并对合成工艺进行优化,所得适宜工艺条件(以4-溴-3,5-二氟苯胺38.6 mmol计):催化剂对甲苯磺酸用量0.877 8 g,n(马来酸酐)/n(4-溴-3,5-二氟苯胺)=1.2,胺化反应时间为1.5 h,环化反应时间为2 h,产率可达92.6%。The N-[（4-bromo-3,5-difluorine）-phenyl]maleimide was synthesized with maleic anhydride and 4-bromo-3,5-difluoroaniline via the solvent azeotropic method,using p-toluene sulfonic acid as the catalyst and toluene/DMF as the mixed solvent.The chemical structure of the product was confirmed by means of FTIR,1HNMR and 13HNMR methods.The synthesis process was optimized,and the suitable conditions were found as follows（based on 38.6 mmol 4-bromo-3,5-difluoroaniline）,amount of p-toluene sulfonic acid 0.877 8 g,n（maleic anhydride）/n（4-bromo-3,5-difluoroaniline）=1.2,amination reaction time 1.5 h,cyclization reaction time 2 h,with a yield of 92.6%.

关 键 词：N-[(4-溴-3 5-二氟)苯基]马来酰亚胺 马来酸酐 4-溴-3 5-二氟苯胺 耐热改性剂 精细化工中间体 

分 类 号：TQ314.22[化学工程—高聚物工业]