灯盏花素固体脂质纳米粒的制备及体外释放的研究  

Study on Preparation of Breviscapine Solid Lipid Nanoparticles and in vitro Release

作　　者：舒乐新[1] 赵启铎[2] 武昊昀[1] 刘志东[1] 张欣华[1] 张锦玲[1] 

机构地区：[1]天津中医药大学现代中药发现与制剂技术教育部工程研究中心,天津300193 [2]天津中医药大学中药学院,天津300193

出　　处：《辽宁中医杂志》2011年第1期125-127,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国际科技合作项目(2007DFC31670);中国博士后科学基金项目(20090460701);国家科技支撑计划项目(2007BAI47B01);国家科技重大专项(2009ZX09311-002)

摘　　要：目的:制备灯盏花素固体脂质纳米粒。方法:采用乳化超声法制备固体脂质纳米粒,以包峰率为指标,通过正交实验对处方进行优化并考察其体外释放。结果:制备的纳米粒的包封率为52.34%,平均粒径为(128±13)nmz,eta电位为-18.4mV,8h的体外累积释放为81.98%。结论:所用制备工艺简单,可用于制备灯盏花素固体脂质纳米粒。Objective：To prepare Breviscapine solid lipid nanoparticles. Methods：The Breviscapine solid lipid nanoparticles were prepared by emulsification-ultrasonic method. With the entrapment efficiencies as references,the formulation was optimized by the orthogonal design. And study Breviscapine release characteristics from the solid lipid nanoparticles in vitro. Results：The entrapment efficiencies,average particle size and zeta potential of nanoparticle was 52. 34% ,（128 ± 13） nm and-18. 4mV,respectively 81. 98% of the total drug was released in vitro after 8 hours. Conclusion：The production technique is simple,which could be used to prepare Breviscapine solid lipid nanoparticles.

关 键 词：灯盏花素 固体脂质纳米粒 乳化超声法 

分 类 号：R284.2[医药卫生—中药学]