聚乙二醇-聚乳酸嵌段共聚物及其微粒给药系统的研究进展  

Research advance in PEG-PLA block copolymers and its micro-or nano-particles as drug delivery system

作　　者：赵刚[1] 苏庆[1] 李静[1] 于胜海[1] 

机构地区：[1]山东省医学科学院药物研究所,济南250062

出　　处：《中国新药杂志》2011年第1期36-40,共5页Chinese Journal of New Drugs

基　　金：山东省自然科学基金(Y2008C03)

摘　　要：综述可生物降解嵌段共聚物聚乙二醇-聚乳酸(PEG-PLA)及其微粒给药系统在药剂学中的研究与应用。该嵌段共聚物微球能提高蛋白、多肽的稳定性,有利于难溶性药物释放。纳米粒可降低网状内皮吞噬系统的识别与吞噬,改变药物体内分布及清除率,连接识别配体后脑靶向作用显著,具有温敏性和pH敏感性,增加难溶性药物溶解度,且生物相容性良好。PEG-PLA嵌段共聚物微粒给药系统将有广阔的发展和应用前景。This article reviewed pharmaceutical research and application of biodegradable PEG-PLA block copolymers and its micro-or nano-particles as drug delivery system.The microspheres of PEG-PLA block copolymers can enhance the stability of protein and polypeptide,and profit the release of poorly water-soluble pharmaceuticals.The nano-particles can reduce the recognization and phagocytosis of reticuloendothelium phagocytic system,and affect the drug biodistribution and clearance.The nano-particles that connect with recognition ligand have the significant brain targeting.The PEG-PLA nano-particles are thermo-and pH-sensitive,and can also increase the solubility of poorly water-soluble drugs.In addition,they have good biocompatibility.The microcarriers of PEG-PLA block copolymers will be a great deal of development and application as drug delivery systems in the future.

关 键 词：可生物降解 聚乙二醇-聚乳酸 微球 纳米粒 

分 类 号：R943[医药卫生—药剂学]