宫颈高度鳞状上皮内病变治疗后高危型人乳头瘤病毒的消退规律  

Clearance of high-risk human papillomavirus after treatment for high-grade squamous intraepithelial lesions.

作　　者：陈观娣[1] 钱德英[1] 岑坚敏[1] 舒焰红[1] 欧阳云雁[1] 郑有为[2] 

机构地区：[1]广东省医学科学院广东省人民医院妇产科,广东广州510080 [2]广东省医学科学院广东省人民医院检验科,广东广州510080

出　　处：《中国实用妇科与产科杂志》2011年第1期42-44,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：广东省科技计划项目基金(2002B30404)

摘　　要：目的探讨宫颈高度鳞状上皮内病变治疗后高危型人乳头瘤病毒(HPV)的消退规律,了解术后高危型HPV持续感染与病变残留或复发之间的关系。方法对2003年1月至2007年12月在广东省人民医院因宫颈高度鳞状上皮内病变行宫颈电环切除术的502例妇女的随访资料进行回顾性分析。结果术前存在高危型HPV感染的宫颈高度鳞状上皮内病变进行宫颈电环切除术治疗后,术后6、12、18、24个月HPV清除率分别为83.63%、94.39%、97.31%、98.88%。术后高危型HPV持续感染人群病变残留或复发率达26.85%。结论宫颈电环切除术后6个月高危型HPV己大部分消退,术后2年基本完全消退。术后宫危型HPV持续感染是病变残留或复发的高危因素,术后HPV阳性妇女,宜严密随访。Objective To investigate the rate of clearance of high-risk human papillomavirus （HPV） infection after loop electrosurgical excision procedure（LEEP） for high-grade squamous intraepithelial lesions, and to study the relation between high-risk HPV persistent infection and residual/recurrent disease after LEEP. Methods A retrospective study was conducted on 502 women who underwent LEEP for high-grade squamous intraepithelial lesions between January 2003 and December 2007 in the Guangdong General Hospital. Results Among those who were high-risk HPV infected before LEEP, the clearance rate of high-risk HPV was 83.63% , 94. 39% , 97. 31% ,and 98.88% after treatment 6 months, 12 months, 18 months and 24 months, respectively. Of women with high-risk HPV persistent infection after LEEP, 26. 85% developed residual/recurrent disease. Conclusion LEEP is an important treatment for high-grade squamous intraepithelial lesions, and it is a highly effective method of eradicating HPV. HPV-DNA testing is a useful means for monitoring the efficacy of treatments during follow-up. We suggest the initial testing should perform at 6 months for the follow-up.

关 键 词：宫颈高度鳞状上皮内病变 人乳头瘤病毒 

分 类 号：R71[医药卫生—妇产科学]