甘露糖结合凝集素相关的丝氨酸蛋白酶1研究进展  

Development of Mannose-binding Lectin-associated Serine Protease 1

作　　者：张海燕[1,2] 王长法[2] 仲跻峰[2] 杨桂文[1] 安利国[1] 

机构地区：[1]山东师范大学生命科学学院,山东济南250014 [2]山东省农业科学院奶牛研究中心,山东济南250100

出　　处：《中国畜牧兽医》2011年第1期42-47,共6页China Animal Husbandry & Veterinary Medicine

基　　金：国家高技术研究发展计划(863)(2007AA10Z169;2006AA10Z1D9);全国奶牛现代农产品加工技术研发体系(nycytx-0107;nyhyzx07-036-09);山东省良种工程项目(2007LZ10-06);山东省重点科技攻关项目(2009GG20002033)

摘　　要：甘露糖结合凝集素途径是补体激活的一个重要途径,在无特异性免疫应答的生物体内或在机体发生免疫应答之前,凝集素补体途径可发挥主要的防御作用。甘露糖结合凝集素相关的丝氨酸蛋白酶(mannose-binding lectin-associated ser-ine protease,MASP)是凝集素途径的中心蛋白酶分子。甘露糖结合凝集素(mannose-binding lectin,MBL)或纤维胶凝蛋白(fi-colin)分子通过其胶原样区(collagen-like region,CLR)与MBL相关丝氨酸蛋白酶MASP-1或MASP-2结合形成复合物,在其C端糖识别域(carbohydrate recognition domain,CRD)识别、结合病原微生物的糖结构后,可活化MASPs酶原,从而激活补体凝集素途径而发挥天然抗感染免疫效应。The mannose-binding lectin pathway is an important pathway of complement activation.In the absence of specific immune responses in vivo or before immune response occurs in body the lectin complement pathway may play a major role in the defense.Mannose-binding lectin-associated serine protease-1（MASP-1） is an central protease of the complement lectin pathway.Mannose-binding lectin（MBL） or ficolin can form compound with Mannose-binding lectin-associated serine protease（MASPs） through its CLR.After its CRD domain recognize and binding to sugars presented on pathogens,MBL or ficolin can activity the zymogens of MASPs,then activate the complement cascade via lectin pathway to play the function of anti-infection by innate immunity.

关 键 词：补体 MASP-1 结构 功能 

分 类 号：Q556.9[生物学—生物化学]