调脂积冲剂对脂肪肝大鼠胰岛素抵抗(IR)及游离脂肪酸(FFA)的研究  

The Effect of TiaozhiJi Emulsion on Insulin Resistance and FFA of the Fatty Liver Rat

作　　者：潘智敏[1] 申京哲[2] 

机构地区：[1]浙江省中医院,浙江杭州310000 [2]浙江中医药大学,浙江杭州310053

出　　处：《中华中医药学刊》2011年第1期9-11,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省自然科学基金资助项目(Y2080541)

摘　　要：目的:讨论调脂积冲剂对脂肪肝大鼠胰岛素抵抗(IR)及游离脂肪酸(FFA)的影响。方法:将SD大鼠49只,随机分4组,空白对照组、模型对照组、易复善治疗组、中药调脂积冲剂治疗组。采用高脂乳剂建立大鼠脂肪肝模型,以易善复为阳性对照,检测大鼠血清ALT、FFA、FBG,肝组织TC、TG,并采用放免法测定血清胰岛素含量。采用稳态模式评估法(HOMA)评价胰岛B细胞功能。结果:与模型组比较调脂积冲剂治疗组ALT、TG显著改善(P<0.01),FFA有改善(P<0.05)。结论:调脂积冲剂能改善脂肪肝大鼠的ALT水平,以改善大鼠肝功能,该冲剂同时作用于TG、FFA以改善血脂水平。Objective：To investigate the effect of tiaozhiji emulsion on insulin resistance and FFA of the fatty liver rat.Methods： 49 SD male rats,a week after the laboratory feeding adaptation,randomized divided into four groups,the control group,the control group model of fatty liver,fatty liver model of good easy-treatment group,fatty liver Model medicine TiaozhiJi Emulsion treatment group.High-fat emulsion used fatty liver rat model to Essentiale to as a positive control,the use of automatic biochemical analyzer detected TC,TG,,ALT and AST,FBG,Radioimmunoassay for determination of serum insulin levels.B islet cell function evaluation by homeostasis model assessment（HOMA）.Results：The ALT、TG were lower than those of the fatty liver model group（P〈0.01）.TiaozhiJi Emulsion can reduce FFA（P〈0.05）.Conclusion：TiaozhiJi Emulsion can improve blood and the liver lipid metabolism disorders,prevention and treatment of hyperlipidemia,still improveliver function.

关 键 词：脂肪肝 胰岛素抵抗 游离脂肪酸 

分 类 号：R285.5[医药卫生—中药学]