土槐汤及其拆方提取物外用对表皮增生小鼠水份丢失量的基础研究  

Basic study on Tuhuai decoction and its disassembled prescriptions on the amount of water lose in mice with epidermal hyperplasia

作　　者：史月君[1] 李波[1] 宋顺鹏[1] 占城[1] 朱英华[1] 李乔[1] 

机构地区：[1]辽宁省大连市皮肤病医院皮肤科,116021

出　　处：《国际中医中药杂志》2011年第1期18-22,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的 研究局部外用土槐汤及其拆方提取物对表皮增生小鼠表皮功能的影响,为土槐汤局部外用治疗银屑病提供理论依据.方法 根据Denda的方法,用胶带破坏小鼠皮肤屏障功能,制作表皮增生模型.给予土槐汤及其拆方不同浓度水、醇提取物外涂,自开始本实验起,每日用药前,用多功能皮肤生理仪于躯干两侧检测皮肤水分丢失量.结果 土槐汤水、醇提取物均有减少皮肤水分丢失量作用,拆方组中当归组、红花组、丹参组、夏枯草组的水、醇提取物均有减少皮肤水分丢失量作用.结论 土槐汤水、乙醇提取物具有减少皮肤水分丢失量抗增生作用,可以外用治疗银屑病,为临床治疗银屑病奠定前期基础.Objective To study the topical application of Tuhuai decoction and its disassembled prescriptions on skin function of mice with epidermal hyperplasia, and to provide a theoretical basis for the treatment of psoriasis. Methods According to the Denda method, skin barrier function in mice was destructed with tape, to produce epidermal hyperplasia model. Tuhuai decoction and its disassembled prescriptions with different concentrations of water and alcohol extracts were external applied on the mice. Since the beginning of the treatment, loss of skin moisture of both sides the trunk was detected with Multi-functional instrument at every day before using the medicine. Results Tuhuai decoction had function of reducing the amount of water loss of skin. The disassembled prescriptions, such as Angelica group, safflower group, Danshen root group, and water and ethanol extracts of Prtmella group can reduce the amount of water loss of skin effect. Conclusion Water and ethanol extracts of Tuhuai decoction has the functions of reducing water loss of skin and resisting hyperplasia,suitable for treating psoriasis by external application, setting a foundation for clinical treatment of psoriasis.

关 键 词：土槐汤 提取物 表皮增生 基础研究 

分 类 号：R285.5[医药卫生—中药学]