血脂康对压力负荷导致心肌重构的保护作用  

The Effect of Xuezhikang on Myocardial Hypertrophy Caused by Pressure Overload

作　　者：张雪娟[1] 宋力[1] 张爱芳[1] 谭凯[1] 

机构地区：[1]青岛大学医学院附属医院心内科,山东青岛266003

出　　处：《中国药学杂志》2011年第1期31-35,共5页Chinese Pharmaceutical Journal

摘　　要：目的观察血脂康对压力负荷导致心肌重构的影响,并探讨其可能的机制。方法 12周龄雄性Wistar大鼠40只,体重200～250 g,随机分为4组,即正常对照组、假手术组、心肌肥厚组、血脂康组。血脂康组术后予以血脂康0.09 g·kg-1·d-1,将药物按1mL·100g-1溶于生理盐水灌胃,1d1次;其余各组每天1mL·100g-1生理盐水灌胃。通过缩窄腹主动脉的方法制备大鼠心肌肥厚模型,在实验终点于腹腔静脉采血,分离血清,检测白细胞介素1-β(IL-1β)、白细胞介素-4(IL-4)的含量,并于实验结束后处死大鼠,测定其心脏/体重、左心室/体重的比值及病理切片左室壁厚度和心肌细胞直径。结果心肌肥厚组收缩压明显高于正常对照组(P<0.05),而血脂康组血压虽有所下降,但与心肌肥厚组相比差异无统计学意义(P>0.05)。心肌肥厚组的心脏质量/体质量、左心室质量/体质量、血清IL-1β含量、心室壁厚度及心肌细胞直径均明显高于正常对照组(P<0.01),血脂康组治疗后上述指标均明显下降(P<0.01),且与正常对照组及假手术组相比无显著差异(P>0.05);而心肌肥厚组血清IL-4的含量则显著低于血脂康组(P<0.01)。结论血脂康对压力负荷导致的心肌重构具有明显的保护作用,同时伴有致炎因子水平的降低,说明血脂康的保护作用可能与其抗炎作用有关。OBJECTIVE To investigate the protective effect of Xuezhikang on the myocardial hypertrophy caused by pressure overload and it＇s mechanism in rats.METHODS 40 wistar rats were randomized into myocardial hypertrophy group,Xuezhikang group,fake operation group and control group.Pressure overload was achieved by surgical constricting the abdominal aortal.After the operation the rat in drug group were treated with Xuezhikang by intragastric administration（0.09 g·kg^-1 d）,the others were treated with normal saline by intragastric administration at the same time.ALL rats were sacrificed 8 weeks after the operation then the heart weight to body ratio and left ventricular weight to body ratio were measured.Blood samples were extracted from the abdominal vein of the animals,and the sera were collected with hypothermia high speed centrifugation for the measurement of interleukin-1β and interleukin-4.RESULTS Systolic blood pressure（SBP） in myocardial hypertrophy group were significantly higher than that in control group,while in the Xuezhikang group SBP has no significant difference compared with the myocardial hypertrophy group（P〉0.05）.The heart weight to body ratio,the left ventricular weight to body,the levels of serum IL-1β,the thickness of left ventricular wall and the diameters of cadiocytes in myocardial hypertrophy group were significantly higher than that in control group.These indexes were significantly decreased after treatment with Xuezhikang,but compared with control group and sham operation group,there were no difference among them;while the levels of IL-4 in Xuezhikang group were higher significantly than those in myocardial hypertrophy group（P〈0.01）.CONCLUSION Xuezhikang can prevent the myocardial hypertrophy caused by pressure overload and that may attribute to its anti-inflammation effect.

关 键 词：血脂康 心肌重构 保护作用 炎症 

分 类 号：R542.2[医药卫生—心血管疾病]