重型颅脑外伤感染患者替考拉宁经验性治疗疗效分析  

Empirical anti-infectious treatment on severe traumatic brain injury patients by using teicoplanin:curative effect analysis

作　　者：叶宏伟[1] 郑峰[1] 吴晓东[1] 冯玉峰[1] 陆敏[1] 

机构地区：[1]苏州大学附属常熟医院ICU,江苏常熟215500

出　　处：《中华医院感染学杂志》2011年第2期341-342,共2页Chinese Journal of Nosocomiology

摘　　要：目的观察国产替考拉宁经验性治疗重型颅脑外伤感染患者的疗效及安全性。方法对收入重症监护病房(ICU)的重型颅脑外伤发热患者,针对革兰阴性杆菌抗感染治疗3 d体温仍不退,经验性加用国产替考拉宁,疗程14 d,并予纤维支气管镜肺泡灌洗取痰行痰培养,观察治疗前后的体温、白细胞计数、C反应蛋白、肝肾功能、微生物检测结果、简化临床肺部感染评分及药物不良反应。结果患者经验性应用国产替考拉宁抗感染后,86.0%患者在治疗5～7 d后体温下降,伴炎性指标下降;在痰培养阳性患者中细菌清除率为76.2%;无明显不良反应发生。结论国产替考拉宁疗效可靠,适合应用于ICU重型颅脑外伤患者经验性抗感染治疗。OBJECTIVE To observe the therapeutic effectiveness and safety of the indigenous teicoplanin′s empirical anti-infectious treatment on severe traumatic brain injury patients.METHODS The severe traumatic brain injury patients in ICU who had received anti-infectious treatment on Gram-posive cocci infection for 3 days and still had fever were received teicoplanin by infusion for 14 days a course.All patients were performed bacterial culture by method of bronchoalveolar lavage.The body temperature before and after the treatment,WBC,CRP,liver and kidney function,microbiologic examination,classification of pulmonary infection simplification（CPIS） and adverse reactions were observed.RESULTS A total of 86% of the patients showed that inflammatory indicators were dropped after 5-7 days of anti-infection treatment with teicoplanin,coupling with the temperature falling,Bacteria clearance rate was 76.2% in positive sputum cultures.No significant adverse reaction was found.CONCLUSION The curative effect of indigenous teicoplanin is credible and suitable for the empirical treatment on sever traumatic brain injury patients in ICU.

关 键 词：替考拉宁 重型颅脑外伤 经验性抗感染 

分 类 号：R378.1[医药卫生—病原生物学]