兔脑急性出血对脑阻抗影响初步实验研究  

Preliminary experimental study on effects of cerebral impedance with acute cerebral hemorrhage in rabbits

作　　者：吴剑威[1] 张鲁闽[1] 史学涛[2] 董秀珍[2] 

机构地区：[1]南京军区福州总医院医学工程科,福建福州350025 [2]第四军医大学生物医学工程系医学电子工程教研室,陕西西安710032

出　　处：《中国医学装备》2011年第1期6-12,共7页China Medical Equipment

基　　金：国家自然科学基金重点项目(50337020);国家自然科学基金重点项目(50937005);国家重点支撑项目(2006BAI03A14)

摘　　要：目的:研究家兔脑急性出血时脑阻抗的定性变化及频率特性。方法:采用第四军医大学医学电子工程教研室研制的阻抗监护系统,用自体血注入法建立兔脑实质出血模型后对7只家兔进行脑阻抗监测。结果:出血初期,阻抗实部明显下降,虚部变化不明显,但随时间推移,脑阻抗实部、虚部绝对值均明显升高。对兔脑阻抗出血前后数据进行配对t检验,具有显著性差异(P<0.001),有统计学意义。在150s时阻抗实部、虚部、模变化率绝对值随频率升高而升高;900s时,在20kHz频率点,阻抗模变化率绝对值最大(|-3.12%|)。结论:采用电阻抗技术对脑急性出血进行监测是可行的,采用不同的测量频率会得到不同的脑部电阻抗变化量,阻抗最大变化率频率点随时间推移向低频转移。随着时间推移,脑急性出血后阻抗实部、虚部和模变化率的频谱特性在变化中,这意味着以往单一频率的监测并不能全面反映脑急性出血后的阻抗变化信息。0bjective： To study the effects of cerebral impedance and the impedance frequency characteristic with acute cerebral hemorrhage in rabbits. Methods After establishing the rabbit model of cerebral hemorrhage with autologous blood injection in 7 rabbits, with four-electrode method, the cerebral impedance was measured by electrical impedance monitor which made by Faculty of Medical Electronic Engineering, Department of Biomedical Engineering, Fourth Military Medical University. The prompting current was set to 1mA at the frequency of 100Hz, 200Hz, 400Hz, 600Hz, 800Hz, 1KHz, 2KHz, 4KHz, 6KHz, 8KHz, 10KHz, 20KHz, 40KHz, 60KHz, 80KHz, 100KHz, 180KHz. Results：The monitoring results showed that the real part of impedance decreased and the imaginary part did not change significantly at the initial time and two real means are significantly different at the 0.001 level with paired t test. The real and absolute imaginary part of impedance rose over time. The frequency of impedance is proportional to the rate of impedance change at the time of 150s. At the time of 900s, the rate of change of impedance was most obvious at the frequency of 20kHz （where the maximum rate of impedance change, modulus｜-3.12%｜）. Conclusion Bio-impedance measurement techinque can be used as a method of early diagnosis of acute cerebral hemorrhage. Different percentage of impedance change will be obtained with different measure frequency. The frequency where the rate of change of impedance was most obvious shifted to lower frequency over time. With acute cerebral hemorrhage, the real part, imaginary part and modulus spectrum of impedance changes over time, which means it can’t fully reflect the impedance changes of acute cerebral hemorrhage with fixed-frequency.

关 键 词：分装 温度要求 高效蓄冷剂 验证 

分 类 号：TH77[机械工程—仪器科学与技术]