222例活体肾移植供受者HLA分型配合率的分析  

Analysis of the HLA match rate of 222 living-related donors for kidney transplantation

作　　者：徐婉珍[1] 贾保祥[2] 杨慧静[1] 苏京平[1] 马威然[2] 阴桢宏[1] 

机构地区：[1]首都医科大学附属北京友谊医院科研处,北京100050 [2]首都医科大学附属北京友谊医院泌尿科实验室,北京100050

出　　处：《国际外科学杂志》2011年第1期25-27,共3页International Journal of Surgery

摘　　要：目的 研究活体亲属肾移植供受者HLA配合率,为临床选择良好的供受者HLA配型提供参考.方法 对2006年4月-2008年12月间手术的222例活体亲属肾移植患者进行HLA供受者配合率分析.移植受者男性168例,女性54例,最大年龄58,最小年龄10岁;移植供者男性133例,女性89例,最大年龄64岁,最小年龄21岁.结果 87例接受父母移植肾患者HLA-A、B、DR、DQ抗原半相合,其中有14例抗原配合率高于半相合.7例接受子女移植肾患者HLA-A、B、DR、DQ抗原半相合,其中有2例HLA抗原配合率高于半相合.56例接受兄弟姐妹间移植肾患者HLA-A、B、DR、DQ配型完全相配合有12例,34例为半相合,其余为低于半相合或不相合.72例接受其他活体移植的供受者间HLA-A、B、DR、DQ大于半相合的有20例;完全不相合的有5例;虽然HLA抗原配合率大于4个抗原,但并不是半相合抗原的有6例;等于或小于3个抗原配合的有41例.结论 父母、子女及兄弟姊妹间的直系亲属肾移植供受者中HLA配合率高于其他亲属间移植供受者.Objective To study the HLA match rate of 222 living-related donors for kidney transplantation, and to give suggestions for clinical selection of suitable donors and recipients. Methods We analyzed the HLA match rate of 222 kidney transplantations from living relative donors from April 2006 to December 2008. There were 168 male recipients and 54 female recipients. The ages of 222 recipients ranged from 10 to 58. There were 133 male donors and 89 female donors. The ages of 222 recipients ranged from 21 to 64.Results The HLA-A, B, DR, DR, antigens of 87 kidney transplantations from living parental donors were half-matched, of which 14 were higher than half-matched. The HLA-A, B, DR, DQ antigens of 7 kidney transplantations from living children donors were half-matched, including 2 cases higher than half-matched.Among 56 kidney transplantations from living sibling donors, 12 cases were totally mated, 34 cases were half-matched, and the rest were less than half-matched or mismatched. Among 72 kidney transplantations from other living relative donors, 20 cases were higher than half-matched and 5 cases were completely mismatched. More than 4 HLA antigens in 6 cases were matched, but not half-matched. Three HLA antigens or less were matched in 41 cases. Conclusion The HLA match rates from living parental, children, or sibling donors were higher than other relative donors.

关 键 词：活体肾移植 亲属 配合率 

分 类 号：R699.2[医药卫生—泌尿科学]