脱氧新羟曲霉酸的分离纯化和结构鉴定  

Isolation and structure identification of desoxyneohydroxyaspergillic acid

作　　者：刘伟[1] 黄明玉[1] 田德峰[1] 杨媛[1] 白硕可[1] 巫晔翔[1] 余利岩[1] 洪斌[1] 姜威[1] 司书毅[1] 

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《中国抗生素杂志》2011年第1期11-13,29,共4页Chinese Journal of Antibiotics

基　　金：国家自然科学基金面上项目(30472026);十一五"重大新药创制"国家科技重大专项(2009ZX09301-003);"十一五"国家科技支撑计划(2008BAI64B02)资助

摘　　要：目的研究曲霉菌2101发酵液中上调高密度脂蛋白受体表达的活性成分。方法利用大孔吸附树脂对发酵液中活性成分进行吸附和分步洗脱,用制备高效液相色谱进行精制,紫外、红外、高分辨质谱和核磁共振进行波谱分析。结果分离得到一个纯化合物2101C。结论经波谱分析,2101C为一新结构的化合物脱氧新羟曲霉酸。Objective To study the active high density lipoprotein（HDL） receptor expression upregulator from the fermentation broth of Aspergillus sp. 2101. Method Active components were absorbed by macroporous absorption resin and eluted by acetone aqueous solution. Purified components were isolated by preparative HPLC and elucidated by spectral analysis. Result One pure component 2101C was isolated. Conclusion 2101C was identified as a new aspergillic acid derivative named as desoxyneohydroxyaspergillic acid.

关 键 词：高密度脂蛋白受体表达上调剂 曲霉菌2101 2101C 脱氧新羟曲霉酸 

分 类 号：R978.7[医药卫生—药品]