他克莫司和子囊霉素电喷雾多级质谱负离子模式下的裂解分析  

Study on the fragmentation pathway of tacrolimus and ascomycin by ESI MS^n under negative mode

作　　者：陈宇翔[1] 谢颖[1] 温耀明[1] 郑军荣[1] 乐占线[1] 周璟明[1] 郑卫[1] 

机构地区：[1]福建省微生物研究所,福州350007

出　　处：《中国抗生素杂志》2011年第1期25-29,共5页Chinese Journal of Antibiotics

摘　　要：目的应用电喷雾多级质谱法分析他克莫司(FK506)和子囊霉素(FK520)在负离子模式下的特征碎片离子和裂解规律。方法采用电喷雾电离离子阱多级质谱,极性检出模式为负离子模式。结果获得他克莫司和子囊霉素在负离子模式下的质谱裂解规律。结论该质谱裂解规律可应用于他克莫司及其类似物的快速结构解析、定量分析和药动学研究。Objective Electrospray ionization tandem mass spectrometric method was applied to the investigation of structural characterization of tacrolimus and ascomycin. Methods Based on electrospray ionization tendam mass spectrometry under negative mode. Results The fragmentation pathways of tacrolimus and ascomycin in MS under negative mode were got. Conclusion These characteristic fragmentation patterns are useful in rapid structural identification, quantitative analysis and pharmacokinetic study of Tacrolimus analog.

关 键 词：电喷雾多级质谱 他克莫司 子囊霉素 质谱裂解规律 

分 类 号：R917[医药卫生—药物分析学]