蛇床子素非离子囊泡的制备和质量评价  

Preparation and Quality Evaluation of Osthole Niosomes

作　　者：陈洪轩[1,2] 徐志杰[2] 肖衍宇[3] 

机构地区：[1]河南大学药物研究所 [2]河南大学药学院,河南开封475004 [3]中国药科大学药学院,江苏南京210009

出　　处：《中国医药工业杂志》2011年第1期33-37,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用薄膜分散-超声法制备蛇床子素非离子表面活性剂囊泡,以包封率为指标通过正交设计优化处方和工艺。并考察了所得优化囊泡的形态、平均粒径和分布、包封率及体外释药行为。结果表明,制品外观呈球形或椭圆形,平均粒径为(246.1±12.3)nm,多分散系数为0.171,包封率为87.4%,体外释药行为符合Higuchi方程(r=0.998 2)。The non-ionic surfactant based vesicles （niosomes） loaded with osthole were prepared by film dispersion-ultrasonic method. The formulation and preparation were optimized by orthogonal design with the encapsulation efficiency as the evaluation parameter. The appearance, mean diameter and distribution, encapsulation efficiency and in vitro release of the optimized niosomes were investigated. The results showed that the niosomes were spherical or elliptic with the mean diameter of （246.1±12.3）nm and polydispersity index of 0.171. Encapsulation efficiency of niosomes were 87.4%. The in vitro release behavior was fitted to Higuchi equation （r=0.998 2）.

关 键 词：蛇床子素 非离子表面活性剂囊泡 薄膜分散-超声法 包封率 体外释放 

分 类 号：R944.9[医药卫生—药剂学]