注射用盐酸甲氯芬酯的赤藓红B增色分光光度法测定  

Hyperchromic Spectrophotometric Determination of Meclofenoxate Hydrochloride for Injection with Erythrosin B

作　　者：马卫兴[1,2] 周岩[1] 王悦[1] 包龙丽[1] 

机构地区：[1]淮海工学院化学工程学院 [2]江苏省海洋资源开发研究院,江苏连云港222005

出　　处：《中国医药工业杂志》2011年第1期57-59,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了赤藓红B增色分光光度法测定注射用盐酸甲氯芬酯。利用盐酸甲氯芬酯与赤藓红B在pH 2.6的Clark-Lubs缓冲溶液中发生相互作用,形成摩尔比为1∶1的离子缔合物而使体系增色,该离子缔合物的最大吸收波长在554 nm处,表观摩尔吸光系数ε_(554)为1.618×10~4L·mol^(-1)·cm^(-1),盐酸甲氯芬酯在1～10μg/ml浓度范围内服从比耳定律。A hyperchromic spectrophotometric method was established for the determination of meclofenoxate hydrochloride for injection, based on the hyperchromic reaction of meclofenoxate hydrochloride with erythrosin B to form ion association complex in the Clark-Lubs buffer at pH 2.6, whose maximum wavelength was 554 nm. The apparent molar absorptivity of complex was 1.618×10^4L·mol-1·cm-1. Meclofenoxate hydrochloride obeyed the Beer＇s law in the concentration range of 1 - 10 μg/ml.

关 键 词：盐酸甲氯芬酯 赤藓红B 分光光度法 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.32[化学工程—制药化工]