男性雄激素缺乏症与代谢综合征  

The Role of Late-onset Hypogonadism in Males in the Metabolic Syndrome

作　　者：关迪[1] 谷翊群[1] 

机构地区：[1]国家人口计生委科学技术研究所男性临床研究室,北京100081

出　　处：《国际生殖健康／计划生育杂志》2011年第1期21-25,共5页Journal of International Reproductive Health/Family Planning

摘　　要：代谢综合征主要表现为腹型肥胖、糖耐量异常、高血压、血脂异常以及炎症和血栓状态。血清睾酮水平低下与代谢综合征密切相关,是糖尿病、动脉粥样硬化、心血管疾病的独立危险因素。横断面流行病学研究结果表明,血清睾酮和胰岛素敏感性有直接关系,患者的低睾酮水平增加其患2型糖尿病的风险,血清睾酮和性激素结合球蛋白水平低下能预测代谢综合征发生率较高。睾酮补充治疗能减少体脂含量、减少胰岛素抵抗和改善血糖控制,能抑制糖尿病和动脉粥样硬化的发展。血清低睾酮水平应该作为代谢综合征定义的要素之一。The main characteristics of the metabolic syndrome are visceral obesity,glucose intolerance,raised blood pressure,dyslipidaemia,inflammation and thrombosis.Low testosterone levels are associated with the metabolic syndrome closely.The metabolic syndrome is a clustering of risk factors predisposing to diabetes mellitus,atherosclerosis and cardiovascular morbidity and mortality.Cross-sectional epidemiological studies reported a direct correlation between plasma testosterone level and insulin sensitivity,and low testosterone levels are associated with an increased risk of type 2 diabetes mellitus.Lower total testosterone and sex hormone-binding globulin predict a higher incidence of the metabolic syndrome.There were also some clinical trials showing improvements in insulin resistance and glycaemic control with testosterone supplement therapy.Administration of testosterone to hypogonadal men reverses the unfavorable risk profile for the development of diabetes and atherosclerosis.The lower serum T level should be an element in the definition of the metabolic syndrome.

关 键 词：睾酮 代谢综合征X 性腺功能减退症 胰岛素抗药性 糖尿病 2型 

分 类 号：R588[医药卫生—内分泌] R589[医药卫生—内科学]