中国湛江木榄(Bruguiera gymnorrhiza)的化学成分研究  

Chemical constituents of mangrove plant Bruguiera gymnorrhiza

作　　者：蔡由生[1] 刘海利[1] 龚景旭[1] 郭跃伟[1] 

机构地区：[1]中国科学院上海药物研究所国家新药研究重点实验室,上海201203

出　　处：《中国海洋药物》2011年第1期15-18,共4页Chinese Journal of Marine Drugs

基　　金：国家科技重大专项(Nos.2009ZX09301-001和2009ZX09103-060);国家自然科学基金(Nos.40976048和81072572)

摘　　要：目的对采自中国湛江红树植物木榄的乙酸乙酯萃取部分进行深入系统的化学成分研究。方法采用硅胶柱色谱、凝胶柱色谱等手段,结合理化性质和波谱数据,对木榄的乙酸乙酯萃取部分的化合物进行分离鉴定。结果从木榄的乙酸乙酯萃取部分中分离得到6个化合物。经现代波谱学分析(1H-NMR,2DNMR,MS等),分别鉴定为:细胞松弛素D(cytochalasin D,1);孢松菌素D(zygosporin D,2);petasol(3);sporogen AO-1(4);6-dehydropetasol(5)和3α-hydroxy-11-peroxyl-eremophila-6,9-dien-8-one(6)。结论化合物1～6均为首次从红树科植物中分离得到。Objective To study the chemical constituents in EtOAc extract of the aerial part of Bruguiera gymnorrhiza.Methods The compounds were isolated by column chromatography over silica gel,sephadex LH-20,and their structures were elucidated by means of spectral analysis.Results Six compounds were isolated and identified as cytochalasin D（1）,zygosporin D（2）,petasol（3）,sporogen AO-1（4）,6-dehydropetasol（5）,and 3α-hydroxy-11-peroxyl-eremophila-6,9-dien-8-one（6）.Conclusion Compounds 1～6 were isolated from this plant for the first time.

关 键 词：红树科 木榄 细胞松弛素 孢松菌素 Eremophilane倍半萜 

分 类 号：R931.7[医药卫生—生药学] R917[医药卫生—药学]