机构地区:[1]首都医科大学附属北京儿童医院心脏中心,北京100045
出 处:《实用儿科临床杂志》2011年第1期16-18,共3页Journal of Applied Clinical Pediatrics
摘 要:目的探讨基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶组织抑制物-1(TIMP-1)在心内膜弹力纤维增生症(EFE)患儿心室重构发病中的作用。方法选择2007年3月-2008年5月首都医科大学附属北京儿童医院心脏中心收治的20例EFE患儿(EFE组),同期选择门诊26例健康体检婴幼儿作为健康对照组。根据预后将EFE患儿分组,死亡及病情无缓解者为危重组(n=5),病情缓解者为普通组(n=15)。采用ELISA法测量各组血清MMP-9及TIMP-1水平。应用SPSS11.5软件对数据进行统计学分析。结果 EFE组和健康对照组年龄、性别构成比较差异均无统计学意义,体质量比较差异有统计学意义[(9.00±2.27)kgvs(10.03±1.92)kg,P<0.01]。EFE组与健康对照组血清MMP-9[(568.1±349.2)μg.L-1vs(446.4±239.8)μg.L-1]、TIMP-1[(342.6±114.2)μg.L-1vs(313.3±60.5)μg.L-1]水平及MMP-9/TIMP-1比值[(1.8±1.3)vs(1.5±0.8)]比较差异均无统计学意义(Pa>0.05)。健康对照组、普通组和危重组MMP-9[(446.40±239.80)μg.L-1vs(552.11±404.12)μg.L-1vs(559.59±205.35)μg.L-1]、TIMP-1[(313.30±60.50)μg.L-1vs(323.30±118.37)μg.L-1vs(381.87±121.06)μg.L-1]水平及MMP-9/TIMP-1比值[(1.5±0.8)vs(1.9±1.5)vs(1.5±0.3)]比较差异均无统计学意义(Pa>0.05)。结论 MMP-9/TIMP-1在EFE心室重构的发病机制中可能无明显作用。Objective To explore the effect of matrix metalloproteinase-9(MMP-9)and tissue inhibitor metalloproteinase-1(TIMP-1)in the pathogenesis of ventricular remodeling in children with endocardial fibroelastosis(EFE).Methods A prospective comparison of 20 children diagnosed as EFE at the Heart Center of Beijing Children′s Hospital Affiliated to Capital Medical University during Mar.2007 to May 2008 were conducted as EFE group,and 26 healthy children with the same age were select as healthy control guoup.The EEF children were further subdivided into common group in which patientsl symptoms improved with treatment(n=15) and crisis group(n=5) in which the children did not improve or died.The plasma contents of MMP-9 and TIMP-1 were measured using enzyme-linked immunosorbent assay.The data were calculated using SPSS 11.5 software.Results There wers no differences of sex and age between the EFE group and healthy control group,but the weight was significantly different between EFE group and healthy control group[(9.00±2.27) kg vs(10.03±1.92) kg,P0.01].The mean MMP-9 level in EFE group was(568.1±349.2) μg.L-1 and that in health control group was(446.4±239.8) μg.L-1;the mean value of TIMP-1 was(342.6±114.2) μg.L-1 in EFE group and(313.3±60.5) μg.L-1 in healthy control group,there were no significant difference between both groups(Ρa0.05).There was no significant difference of mean ratio of MMP-9/TIMP-1 between healthy control group(1.5±0.8) and EFE group(1.8±1.3)(P0.05).Among healthy control group,common group and crisis group,mean TIMP-9 levels were(446.40±239.80) μg.L-1,(552.11±404.12) μg.L-1 and(559.59±205.35) μg.L-1,respectively.Mean TIMP-1 values were(313.30±60.50) μg.L-1,(323.30±118.37) μg.L-1,and(381.87±121.06) μg.L-1,respectively.None of these values were significantly different(Ρa0.05).There was no significant difference of mean ratio of MMP-9/TIMP-1 among healthy control group(1.5±0.8),common group
关 键 词:心内膜弹力纤维增生症 基质金属蛋白酶-9 基质金属蛋白酶组织抑制物-1 儿童
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