枫香槲寄生三萜及三萜皂苷类成分研究  

Triterpenoids and triterpenoid saponins of Viscum liquidambaricolum

作　　者：杨燕军[1] 陈梅果[1] 沙聪威[2] 

机构地区：[1]广东食品药品职业学院,广东广州510520 [2]广东省药物研究所,广东广州510440

出　　处：《中国中药杂志》2011年第2期162-165,共4页China Journal of Chinese Materia Medica

基　　金：广东省中医药局重点及一般项目(2008435;2008200);广东省自然科学基金项目(9151063201000036)

摘　　要：目的:进一步研究枫香槲寄生Viscum liquidambaricolum的化学成分。方法:用硅胶、ODS中压制备、SephadexLH-20等色谱方法进行化合物的分离纯化,采用理化数据分析和波谱分析方法鉴定化合物的结构。结果:从枫香槲寄生分离并鉴定出8个三萜类化合物,分别为杨梅二醇(myricadiol,1),马斯里酸(maslinic acid,2),2α,3β,23-三羟基-12-烯-28-齐墩果酸(2α,3β,23-trihydroxyolean-12-en-28-oic acid,3),齐墩果酸-3-O-β-D-吡喃葡萄糖醛酸苷-6′-O-甲酯(oleanolic acid 3-O-β-D-glu-curonopyranoside-6′-O-methyl ester,4),齐墩果酸3-O-β-D-吡喃葡萄糖醛酸苷(oleanolic acid 3-O-β-D-glucuropyranoside,5),齐墩果酸-3-O-β-D-吡喃葡萄糖-(1→2)-α-L-吡喃阿拉伯糖苷(oleanolic acid 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside,6),3-O-β-D-吡喃葡萄糖醛酸-齐墩果酸-28-O-β-D-吡喃葡萄糖苷(3-O-β-D-glucuronopyranosyl-oleanolic acid-28-O-β-D-glucopyr-anoside,7),3-O-β-D-吡喃葡萄糖醛酸-齐墩果酸-28-O-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖苷(3-O-β-D-glucuronopyranosyl-oleanolic acid-28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside,8)。结论:化合物1～8均为首次从本植物中分离得到,亦为首次从槲寄生属植物中分离得到。To study the triterpenoids and triterpenoid saponins of Viscum liquidambaricolum further, chemical constituents were isolated from the title plant by various chromatographic methods such as silica gel and ODS medium pressure column chromatography, Sephadex LH-20 column chromatography, et al. Their structures were elucidated by physiochemical properties and spectral analysis. Eight triterpenoids and triterpenoid saponins were isolated and identified as myricadiol（ 1）, maslinic acid（2）, 2α,3β,23-trihydroxyolean-12-en-28-oic acid （3）, oleanolic acid 3-O-β-D-glucuronopyranoside-6＇-O-methyl ester （4）, oleanolic acid 3-O-β-D-glncuropyranoside （5）, oleanolic acid 3-O-β-D-glucopyranosyl- （ 1→2 ） -a-L-arabinopyranoside （ 6 ）, 3-O-β-D-glucuronopyranosyl-oleanolic acid- 28-O-β-D-glucopyranoside （ 7 ）, 3-O-β-D-glucuronopyranosyl-oleanolic acid-28-O-β-D-glucopyranosyl-（ 1 → 6 ） -β-D-glueopyranoside （8）. Compounds 1-8 were isolated from this plant and the genus for the first time.

关 键 词：枫香槲寄生 化学成分 三萜类 

分 类 号：R284[医药卫生—中药学]