壳聚糖/羟基磷灰石复合骨折内固定棒材的制备与性能研究  

Study on preparation and performance of the CS/HA rods for bone Internal fixation

作　　者：孙珍珍[1] 蔡汝汝[1] 蒲曦鸣[1] 杨云[1] 姚清清[1] 侯振清[1] 张其清[1,2] 

机构地区：[1]厦门大学生物医学工程研究中心/材料学院,福建省生物医学工程重点实验室,厦门市生物医学工程技术研究中心,福建厦门361005 [2]中国医学科学院中国协和医科大学生物医学工程研究所,天津市生物医学材料重点实验室,天津300192

出　　处：《功能材料》2011年第1期128-131,共4页Journal of Functional Materials

基　　金：“十一五”国家科技支撑计划资助项目(2007BAD07B05);福建省海洋与渔业局重点资助项目(闽海渔合同号[2008]1-11)

摘　　要：采用原位沉析法制备了壳聚糖/羟基磷灰石(CS/HA)复合棒材。用预先沉积的壳聚糖膜将含有Ca、P源的壳聚糖溶液与凝固液隔离,同时控制壳聚糖沉积与羟基磷灰石前驱体转化为羟基磷灰石的过程,使二者得以均匀复合。燃烧试验结果表明无机成分均匀分散于壳聚糖中,FT-IR、XRD和TEM测试证实原位生成羟基磷灰石,弯曲强度测试结果表明,原位沉析法制备的材料具有层状结构,CS/HA(质量比20/4)复合材料弯曲强度达133MPa,弯曲模量6.8GPa。The CS/HA composites with a high performance were prepared via in situ precipitation.In this method,the calcium and phosphorus precursors were added into the solution of chitosan firstly,dispersed homogeneously.The pre-precipitated CS membrane controlled the process of CS precipitation and transformation of HA from the precursors.The results of burn-out tests indicated that the inorganic component was dispersed uniformly in chitosan matrix.FT-IR,XRD and TEM were carried out to determine the components and morphology of CS/HA.The results showed that the inorganic component was exactly nano-sized HA.The mechanical properties of CS/HA were evaluated by the three point bending test.The bending strength and modulus of CS/HA（mass ratio 20/4） were 133MPa and 6.8GPa.

关 键 词：壳聚糖 羟基磷灰石 原位沉析 内固定 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317.9[医药卫生—基础医学]