盐酸洛非西定片与美沙酮口服液控制阿片戒断症状的临床对照观察  

A CLINICAL OBSERVATION ON THE CONTROL OF OPIOID WITHDRAWAL SYNDROMES BY LOFEXIDINE VERSUS METHADONE

作　　者：金俊[1] 王佩贤[1] 铁恩贵[1] 曾恒[1] 徐本树[1] 王艳芬[1] 陈君[1] 孙志伟[1] 

机构地区：[1]北京市安康医院戒毒中心

出　　处：《中国药物依赖性杂志》1999年第3期217-219,共3页Chinese Journal of Drug Dependence

摘　　要：目的··：了解盐酸洛非西定片（ＬＦＸ）控制阿片戒断症状的疗效。方法··：采用随机双盲方法，以美沙酮口服液（Ｍ）作为对照组，进行临床观察比较。结果··：盐酸洛非西定片能有效控制常见的戒断症状；治疗早期Ｍ组效果优于ＬＦＸ组（Ｐ＜０．０１），随着治疗的进行，两药控制戒断症状差异无显著性（Ｐ＞０．０５），而后期ＬＦＸ组效果优于Ｍ组（Ｐ＜０．０１）。不良反应盐酸洛非西定片组出现较多，主要表现为头晕、恶心、口干、乏力等，但随着剂量减少，不良反应也随之缓解。结论··：由于洛非西定本身不具有依赖性，因此是一种值得推广的戒毒药物。Objective: to evaluate the clinical efficacy of lofexidine hydrochloride tablets (LFX) in the treatment of opium withdrawal symptoms. Method: A random, double-blind method was adopted, methadone group served as the control. Result: LFX was effective in controlling opium withdrawal symptoms, however, in the early stage of treatment, methadone seemed more effective than LFX (P<0.01), this difference disappeared as the treatment went on (P<0.05);in the late stage, LFX is more effective than methadone (P<0.01),the side-effects produced by LFX in general were dizziness, nausea, drymouth, fatigue and so on, which relieved gradually or disappeared as the dose decreased. Conclusion: LFX is a highly effective detoxicant without dependence producing potential.

关 键 词：阿片类依赖 戒断症状 盐酸洛非西定片 美沙酮 

分 类 号：R595.505[医药卫生—内科学]