TNF-α介导的NF-κB信号通路在肺纤维化中的作用  

ROLE OF TUMOR NECROSIS FACTOR-ASIGNALING PATHWAY MEDIATED BY NUCLEAR FACTOR KAPPA B IN PULMONARY FIBROSIS

作　　者：田莉[1] 王献华[1] 马小兵[1] 赵静[1] 

机构地区：[1]华北煤炭医学院病理学教研室,唐山063000

出　　处：《现代预防医学》2011年第2期361-363,365,共4页Modern Preventive Medicine

基　　金：河北省自然科学基金(C2008001007);河北省科学技术研究与发展计划项目(09276199D)

摘　　要：肺纤维化是多种原因引起的慢性肺疾病的共同结局,其病变特点是肺部炎症导致肺泡持续性损伤、反复破坏、修复、重建及细胞外基质的过度沉积。肿瘤坏死因子α(TNF-α)是一种细胞毒因子,在肺纤维化的发病机制中起着关键作用。近年的研究表明,TNF-α可通过激活NF-κB信号通路,在肺纤维化的形成过程中发挥作用。现对TNF-α介导的NF-KB信号通路在肺纤维化中的作用作一综述。Pulmonary fibrosis is the common outcome of chronic lung diseases caused by a variety of reasons,and is characterized by pulmonary inflammation,leading to persistent damage,repeated damage,repair,reconstruction,and excessive extracellular matrix deposition.Tumor necrosis factor-α（TNF-α）is a cytotoxic factor,playing a key role in the pathogenesis of pulmonary fibrosis.Recent studies show that TNF-α plays a role in activating NF-κB signaling pathway in pulmonary fibrosis.Role of tumor necrosis factor-αsignaling pathway mediated by nuclear factor kappa B in pulmonary fibrosis is reviewed.

关 键 词：肺纤维化 肿瘤坏死因子-Α 核因子-ΚB信号通路 

分 类 号：R56[医药卫生—呼吸系统]