芦丁明胶微球的制备工艺研究及性能表征  

Preparing rutin gelatin microspheres and characterization

作　　者：苏秀霞[1] 赵艳[1] 李仲谨[1] 陈红海[1] 

机构地区：[1]陕西科技大学教育部轻化工助剂化学与技术重点实验室,西安710021

出　　处：《食品科技》2011年第1期219-223,共5页Food Science and Technology

基　　金：国家自然科学基金资助项目(50573046);陕西省教育厅产业化培育项目(02JC05);陕西省星火计划(2004kx3-10)

摘　　要：以明胶为载体,液体石蜡为油相,Span80为乳化剂,戊二醛为交联剂,采用乳化交联法制备芦丁明胶微球,通过单因素实验和正交设计实验筛选出最佳工艺条件,并对工艺重现性进行了考察。利用扫描电镜、红外光谱、X衍射图谱等手段对产物进行了表征,计算出明胶微球的载药量和包封率。结果表明:芦丁用量及交联剂用量是影响微球性能的主要因素;微球形态圆整、表面光滑、大小均匀,其粒径为5～20μm,载药量为3.55%,包封率为94.5%。In this study the single factor experiment and orthogonal experimental were designed to optimize the best techniques of preparing rutin gelatin microspheres.Rutin gelatin microspheres were prepared by emulsion chemical-cross linking method with degradable gelatin as carrier,liquid paraffin as oil phase,Span80 as emulsifier,and the technique reproducibility of microspheres was studied.The surface morphology of the microspheres was observed by SEM,the formation of the drug microspheres was confirmed by FT-IR and XRD.The drug loading,the encapsulation efficiency and stability of the microsphere were examined.Microspheres with good shape,smooth surface and narrow size distribution were prepared.The average diameter of microspheres was 5~20 μm,the loading amount of medicine was 3.55% and encapsulation efficiency was 94.5%.

关 键 词：芦丁 微球 正交设计 乳化交联 

分 类 号：R944.9[医药卫生—药剂学]