山茱萸总苷分散片的处方工艺研究  

Preparation Process of Dispersible Tablets of Total Glycosides from Cornus officinalis

作　　者：孙志明[1] 李小娜[2] 陈苹苹[2] 徐海燕[2] 周洁[2] 

机构地区：[1]华北煤炭医学院附属医院药剂科,唐山市063000 [2]华北煤炭医学院药学系,唐山市063000

出　　处：《中国药房》2011年第3期219-221,共3页China Pharmacy

基　　金：河北省科学技术研究与发展指导计划课题(07276454)

摘　　要：目的:研究山茱萸总苷分散片的处方工艺。方法:以分散均匀性和硬度为综合指标,筛选山茱萸总苷分散片最佳的制备工艺,并测定莫诺苷和马钱苷的溶出度。结果:最佳制备工艺为浸膏:淀粉:微晶纤维素=1:1:0.4,加4%交联聚维酮和0.2%硬脂酸镁;制得的分散片的分散时间<3min,硬度为40～60N;莫诺苷和马钱苷的的平均溶出度在45min时分别为111.65%和101.81%。结论:该处方工艺简单、经济,所制成的分散片崩解迅速、药物溶出快。OBJECTIVE：To study the preparation process of dispersible tablets of total glycosides from Cornus officinalis.METHODS：The preparation process of dispersible tablets of total glycosides from C.officinalis was optimized using disperse homogeneity and hardness as index,and the dissolution rates of morroniside and loganin were determined.RESULTS：The optimal preparation process was as follows：extract：starch：microcrystalline cellulose was equal to 1：1：0.4;adding into 4% PVPP and 0.2% magnesium stearate;the disintegration time of tablets was less than 3 min;the hardness was 40-60 N.The average dissolution rate of morroniside and loganin was 111.65% and 101.81% at 45 min respectively.CONCLUSION：The process is simple and economical.Prepared tablet is collapsed rapidly and dissolved fast.

关 键 词：山茱萸总苷 分散片 制备工艺 

分 类 号：R283.64[医药卫生—中药学] R284.2[医药卫生—中医学]