盐酸莫西沙星致不良反应44例文献分析  

Literature Analysis of 44 ADR Cases Induced by Moxifloxacin Hydrochloride

作　　者：欧阳小青[1] 蔡德[1] 林燕[1] 

机构地区：[1]汕头大学医学院第一附属医院,汕头市515041

出　　处：《中国药房》2011年第4期323-324,共2页China Pharmacy

摘　　要：目的:探讨盐酸莫西沙星致不良反应(ADR)的类型及特点,为临床合理用药提供参考。方法:对2002年1月-2010年8月以来国内公开发行的医药期刊报道的盐酸莫西沙星致ADR,共计44例进行分类统计、分析。结果:ADR临床主要表现为中枢及外周神经系统损害(17.4%)、交感副交感神经系统损害(11.8%)、呼吸系统损害(10.4%)、皮肤及其附件损害(9.0%)、胃肠系统损害(8.3%)等;有基础疾病的中老年人ADR发生率高;ADR治愈16例(36.4%),好转26例(59.1%),有后遗症2例(4.5%)。结论:临床应重视盐酸莫西沙星的ADR,坚持合理用药。OBJECTIVE：To evaluate the type and characteristics of adverse drug reactions（ADR） induced by oxifloxacin hydrochloride,and to provide reference for rational use of drugs in the clinic.METHODS：44 moxifloxacin hydrochloride-inducing ADR cases reported in domestic publication medicine periodicals since 2002.1.-2010.8.were analyzed statistically.RESULTS：The clinical main manifestations were central and perpheral nervous system disorders（17.4%）,sympathetic and parasympathetic nervous system disorders（11.8%）,respiration system disorder（10.4%）,lesion of skin and appendants（9.0%）,gastro-intestinal system disorders（8.3%）,the incidence of ADR in middle and old aged people was high,16 cases were cured（36.4%）,26 cases were improved（59.1%）,2 cases suffered from sequelae（4.5%）.CONCLUSION：Great importance should be attached to ADR induced by moxifloxacin hydrochloride and rational use of drugs.

关 键 词：盐酸莫西沙星 药品不良反应 合理用药 

分 类 号：R969.3[医药卫生—药理学]