SOD配合物对过量摄氟大鼠肝肾损害保护作用的形态学研究  

Protective effcets of S O D-m odel m atch on liver and kidney dam age in rats fed w ith overdose fluoride

作　　者：管考鹏[1] 王志成[1] 富德[1] 廖展如[2] 王彤[1] 闫景龙[1] 关德宏[1] 吕松岑[1] 吴莹[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医学院,黑龙江哈尔滨150086 [2]华中师范大学化学系,湖北武昌430079

出　　处：《中国地方病学杂志》1999年第5期323-325,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金

摘　　要：目的　观察 Ｓ Ｏ Ｄ 模型配合物—络合铜 Ｃｕ２（ Ｄ Ｔ Ｐ Ｂ）对大鼠因过量摄氟引起的肝肾损害有无保护作用。方法　将４０只雄性 Ｗ ｉｓｔａｒ 大鼠随机分为３组：正常对照组、过量摄氟组、络合铜保护组。饲养５个月后，分别检测血氟、尿氟含量并观察肝肾的显微结构。结果　正常对照组及络合铜保护组血氟无显著差异，过量摄氟组血氟明显高于前两组。过量摄氟组及络合铜保护组尿氟含量增加，后者更高。肝肾组织显微结构的观察显示，氟组大鼠肝肾细胞有明显的损伤，而络合铜保护组仅有轻微损害。结论　络合铜对过量摄氟大鼠的肝肾有一定的保护作用。Objective A I M to explore the protective effects of S O D m odel coordination com pound Cu2( D T P B) on liver and kidney dam age caused by overdose fluoride. M ethods Forty m ale W is tar rats w ere divided random ly into three groups: the norm al control group, fluoride group and theadding Cu2 ( D T P B) group. Fed five m onths, serum and urine fluoride w ere exam ined, and the m i crostructure of the livers and kidneys w ere observed. Results The serum fluoride levels of the fluoridegroup w ere significantly higher than that of other tw o groups. But there w as no m arked difference be tw een the norm algroup and the Cu2( D T P B) groups. The urine fluoride levels of the fluoride group and Cu2( D T P B) group increased rem arkably,especially the latter. As for the m icrostructure,the livers andkidneys of the fluoride group w ere severely dam aged,but the dam age of the Cu2( D T P B) group w as notobvious com pared w ith the norm alcontrol. Conclusions The evidences suggest that Cu2( D T P B) exertsa protective effect on liver and kidney from rats fed w ith overdose fluoride.

关 键 词：SOD 模型配合物 肝 肾 氟中毒 保护作用 地方性 

分 类 号：R599.902[医药卫生—内科学]