实验性氟中毒小鼠肝细胞超微结构的观察  

Observation on the ultrastructure of hepatic cells from m ice w ith experim ental fluorosis

作　　者：钟山[1] 瞿祥虎[2] 钟海 邓铭[1] 任波[1] 

机构地区：[1]湖北医科大学生物学教研室,湖北武汉430071 [2]华中理工大学化学系,湖北武汉430073 [3]武汉第十医院,湖北武汉430034

出　　处：《中国地方病学杂志》1999年第5期326-327,共2页Chinese Jouranl of Endemiology

基　　金：湖北省自然科学基金

摘　　要：目的　进一步研究氟中毒对肝损伤的机制。方法　以实验性氟中毒小鼠为实验对象，在透射电镜下观察其肝细胞超微结构的变化。结果　实验性氟中毒导致小鼠肝细胞广泛损伤，包括肝细胞粗面内质网变得扁平并断裂，线粒体可见明显肿大，其嵴消失或模糊。结论　氟中毒对粗面内质网和线粒体内膜的影响至少是其导致肝细胞损伤的机制之一。Objective The effects of fluorosis on hepatic dam age w ere evaluated. M ethods 8 m ice w ere fed w ith high fluorine w ater to experim entalfluorosis,then the m orphological changesin the ultrastructure of their hepatic cells w ere investigated by m eans of electron m icroscope. Results A w ide dam age in hepatic cell of experim ental fluorosis w as observed,including that therough endoplasm ic reticulum becam e flatter than control and w ere even broken and the m itochon dria w ere inflated significantly,the cristae on the inner m em brane of m itochondria w ere disappearedor unclear. Conclusions The harm ful effects of fluorosis on rough endoplasm ic reticulum and m i tochondrion is at least one of the m echanism s through w hich fluorosis cause hepatic dam age.

关 键 词：氟中毒 肝细胞 粗面内质网 线粒体 超微结构 

分 类 号：R599.902[医药卫生—内科学]