尿白蛋白排泄率异常的2型糖尿病患者尿N-乙酰-β-葡萄糖苷酶、α_1-微球蛋白及视黄醇结合蛋白检测的改变  

The role of combination detection of urinary NAG, α_1-MG, RBP in diagnosing the early renal damage in patients with type 2 diabetes

作　　者：申志祥[1] 陈燕[1] 陈秀益[1] 卞茸文[1] 

机构地区：[1]江苏省老年医学研究所糖尿病防治研究中心,南京210024

出　　处：《中国糖尿病杂志》2011年第1期21-23,共3页Chinese Journal of Diabetes

基　　金：江苏省卫生厅科研项目(H2005017)

摘　　要：目的检测不同尿白蛋白排泄率(UAER)的2型糖尿病(T2DM)患者尿N-乙酰-β-葡萄糖苷酶(NAG)、α1-微球蛋白(α1-MG)、视黄醇结合蛋白(RBP)水平,探讨其对2型糖尿病早期肾损害诊断的应用价值。方法选择我院就诊的T2DM患者196例,健康体检者57名,检测12小时UAER水平。根据UAER水平将T2DM患者分为UAER正常组和异常组。分别检测尿NAG、α1-MG、RBP,肌酐(Cr)水平,并分析各组间差异。结果 196例T2DM患者NAG/Cr、α1-MG/Cr及RBP/Cr水平较健康对照组明显升高(P<0.05);与对照组比较,T2DM患者中UAER正常组及异常组NAG/Cr、α1-MG/Cr及RBP/Cr水平具有显著性差异(P<0.05或P<0.01)。在T2DM患者中,UAER与NAG/Cr、α1MG/Cr及RBP/Cr之间没有相关性,而NAG/Cr与α1-MG/Cr及RBP/Cr之间存在相关性(P<0.01)。T2DM患者中UAER、NAG、α1-MG、RBP联合检测阳性率高于各单一指标的检测阳性率(P<0.05)。结论 T2DM患者联合检测尿NAG、α1-MG、RBP可以提高糖尿病早期肾损害的诊断的敏感性,利于糖尿病肾病的早期预防。Objective To investigate the value of the combination detection of urinary NAG, α1- MG, RBP in diagnosing the early renal damage in patients with type 2 diabetes. Methods 196 patients with type 2 diabetes and 57 healthy cases underwent UAER assay. Patients with type 2 diabetes were divided into non-UAER group and UAER group. The levels of NAG, α1-MG, RBP, UAER and Cr were detected. Results The ratios of NAG/Cr and α1-MG/Cr and RBP/Cr in the patients with type 2 diabetes were higher than those in healthy cases （P〈0. 05）. There were no significant differences in NAG/Cr and α1-MG/Cr between non-UAER group and UAER group. There were no correlations of UAER with ratios of NAG/Cr, α1-MG/Cr, RBP/Cr, while there were significant correlations among NAG/Cr, α1-MG/Cr and RBP/Cr（P〈0.01）. The positive rate of the combination detection of UAER, NAG, α1-MG, RBP was higher than that of the single parameter in the patients with diabetes. Conclusions The combination detection of urinary NAG, α1-MG, RBP could improve the diagnosis of early renal damage in the patients with diabetes.

关 键 词：NAG Α1-MG RBP 尿白蛋白排泄率 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]