不同动物皮肤对小儿腹泻脐贴膏体外经皮渗透的研究  

In vitro transdermal permeability of Xiaoer Fuxie Navel Plaster investigated on different animals’skin

作　　者：蒋俊[1,2] 贾晓斌[2,3] 李平[1] 高成林[2] 王静静[2] 蔡宝昌[3] 吴皓[3] 

机构地区：[1]镇江出入境检验检疫局国家食品添加剂及调味品检测重点实验室,江苏镇江212008 [2]江苏省中医药研究院中药新型给药系统重点实验室,国家中医药管理局中药口服释药系统重点研究室,江苏南京210028 [3]南京中医药大学江苏省中药炮制重点实验室,江苏南京210029

出　　处：《中草药》2011年第1期61-64,共4页Chinese Traditional and Herbal Drugs

基　　金：国家“十一五”科技支撑计划项目(2008BAI53B072);江苏省中医药领军人才项目(2006);江苏省中医药局科研项目(HL07091)

摘　　要：目的考察不同动物皮肤和透皮促进剂不同质量浓度对小儿腹泻脐贴膏的经皮渗透性的影响。方法以小儿腹泻脐贴膏为模型药物,采用Franz扩散池法,以补骨脂素、异补骨脂素为指标成分,比较大鼠腹部皮肤、家兔腹部皮肤、小鼠背部皮肤以及猪耳廊背面皮肤对小儿腹泻脐贴膏的经皮渗透性的差异,同时比较1%、3%、5%氮酮对小儿腹泻脐贴膏的经皮渗透性的影响。结果大鼠腹部皮肤对补骨脂素和异补骨脂素的24 h累积透过量均最大,渗透速率最高;氮酮质量浓度为1%时对补骨脂素和异补骨脂素的透皮促进作用最强。结论选择1%的氮酮作为透皮促进剂,且选用大鼠腹部皮肤作为透皮促进剂筛选的皮肤模型时,小儿腹泻脐贴膏的透皮效果最好。Objective To investigate the effect of different animal’s skin and different concentration of one penetration enhancer on the transdermal permeability of Xiaoer Fuxie Navel Plaster.Methods Using Franz diffusion cell and HPLC,and taking psoralen and isopsoralen as index components,the differences in transdermal permeability of abdominal skin of rats and rabbits,back skin of mice,and ear skin of pigs,and the effects of different concentration of 1%,3%,and 5% of Azone on transdermal permeability of Xiaoer Fuxie Navel Plaster were compared and studied.Results Abdominal skin of rats profited to the transdermal penetration of psoralen and isopsoralen,the 24 h-accumulated permeattion of both psoralen and isopsoralen reached the maximum and the penetration rate was the highest and the effect of penetration enhancers was the strongest at the concentration of 1% Azone.Conclusion The transdermal effect of Xiaoer Fuxie Navel Plaster could be best when choosing 1% Azone as the penetration enhancer and abdominal skin of rats as screening model of penetration enhancer.

关 键 词：小儿腹泻脐贴膏 不同皮肤 补骨脂素 异补骨脂素 经皮渗透 

分 类 号：R284.2[医药卫生—中药学] R286.02[医药卫生—中医学]