白矾对小鼠肠道微生态平衡的影响  

Effect of Alum on Intestinal Microecological Balance in Mice

作　　者：严梅桢[1] 叶文华[1] 宋红月[1] 张粒民 伍迎红[1] 周钟鸣[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国中西医结合杂志》1999年第9期541-543,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金!资助项目 (No.39470 857)

摘　　要：目的 :了解由白矾引起的小鼠肠道微生态平衡失调的程度和细菌对该小鼠肠道粘膜的粘附性。方法 :用白矾 0 2 5 g/kg和 1g/kg两个剂量喂饲小鼠 8周再停药恢复 5周 ,分别对小鼠肠道菌群进行分析 ,并测定试验菌对小鼠肠道粘膜上皮细胞表面的粘附性。结果 :小鼠喂饲白矾 8周后 ,肠道中生理性细菌双歧杆菌和乳杆菌数量明显下降 ,大肠杆菌菌量显著上升。双歧杆菌对小鼠肠道粘膜的粘附率明显低于对照组小鼠 ,大肠杆菌则相反。停药恢复 5周后 ,小鼠紊乱的肠道菌群和两种试验菌对小鼠肠道粘膜的粘附率均基本恢复正常。结论 :小鼠长期服用白矾引起的肠道菌群的失调只是一种暂时的菌量变化 ,消除作用因素后 ,经停药恢复 5周 。To observe the degree of microecological imbalance induced by alum in normal intestine of mice, and the bacterial adherence activity in the intestine of the mice administered orally with alum .Methods: The mice were medicated orally with alum of small and large doses (0.25g/kg and 1g/kg) for 8 weeks, then 5 weeks after stopping administration of alum, microflora analysis and bacterial adherence to intestinal mucosal epithelial cells were carried out respectively. Results: Eight weeks after administration with alum, the counts of Bifidobacteria and Lactobacilli decreased significantly, but the numbers of pathogenetic E.Coli increased significantly. The adherence rate of Bifidobacteria to the enterocytes of mice reduced markedly, but E. Coli was on the contrary of Bifidobacteria. Five weeks after the ceasing of medication, the intestinal flora were balanced, the adherence rate of both strains as mentioned above recovered to normal level. Conclusion: The imbalance of intestinal flora of mice administered with alum for a long time were only the transient change of bacterial counts. The imbalance of intestinal flora and the adherence rate of bacteria regained normal status five weeks after cancelling action factor.

关 键 词：白矾 肠道菌群 微生态平衡 粘附 

分 类 号：R285.1[医药卫生—中药学]