茶碱治疗早产儿原发性呼吸暂停的药效学研究  

Pharmacodynamics of Theophylline in Treatment of Idiopathic Apnea in Premature Infants

作　　者：倪映华[1,2] 朱狄峰[2] 张慧芬[1] 王珏[1] 郦柏平[1] 

机构地区：[1]浙江大学医学院附属儿童医院,杭州310003 [2]浙江大学药学院,杭州310058

出　　处：《中国药学杂志》2011年第2期146-148,共3页Chinese Pharmaceutical Journal

基　　金：浙江省科技计划面上科研项目(2008C33023)

摘　　要：目的研究茶碱治疗早产儿原发性呼吸暂停的药效学,指导临床合理用药。方法 21例诊断为原发性呼吸暂停的早产儿静脉滴注氨茶碱,（7±1）d后采用荧光偏振免疫法测定茶碱血药浓度,记录呼吸暂停次数和给氧条件,观察不良反应。结果测得65.8%（25/38）茶碱血清浓度分布在3~6mg·L-1之间。呼吸暂停治疗有效率为81.0%。茶碱给药后呼吸暂停次数发作明显减少,给药前后对给氧条件无显著差异。其中有3例患儿出现窦性心动过速,7例患儿出现多尿。结论需根据血药浓度和临床表现来共同判定茶碱剂量是否有效。临床需密切关注窦性心动过速和多尿的不良反应。OBJECTIVE To study the pharmacodynamics of theophylline in treatment of idiopathic apnea in premature infants.METHODS The pharmacodynamics of theophylline were studied in twenty-one premature infants who were diagonosed with idiopathic apnea.Serum peak and trough theophylline concentrations were determined on（7±1） d after the first administration by fluorescence polarization immunoassay.Apnea frequency,oxygen supply,heart rate,and urine volume were monitored.RESULTS 65.8% theophylline serum concentrations ranged between 3~6 mg·L-1.Cure rate of idiopathic apnea in premature infants was 81.0%.Apnea incidence decreased significantly during theophylline administration.There was not significant decrease in oxygen supply during theophylline administration.Three premature infants experienced sinus tachycardia.Urorrhagia was observed in seven premature infants.CONCLUSION When judging whether the treatment of idiopathic apnea in premature infants is effective,both of the serum theophylline concentration and clinical response need to be considered.The adverse reactions of theophylline including sinus tachycardia and urorrhagia should be monitored.

关 键 词：茶碱 早产儿原发性呼吸暂停 药效学 

分 类 号：R969[医药卫生—药理学]