孕妇IgG血型抗体效价与ABO新生儿溶血病关系的分析  

Study of the relationship between blood group antibody IgG titer of pregnant women and ABO - HDN

作　　者：李燕琼 

机构地区：[1]河南省驻马店市中心医院,463000

出　　处：《中国医学创新》2011年第2期36-37,共2页Medical Innovation of China

摘　　要：目的探讨孕妇Igc血型抗体效价与AgO新生儿溶血病发生率之间的关系。方法对716例妻子0型Rh阳性而丈夫非O型孕妇做IgG抗-A（B）效价测定，对其中106例有HDN危险的孕妇所生新生儿做HDN血型血清学检查。结果716例O型孕妇中IgG抗-A（B）效价〈64、64、128、256和≥512各组分别占60．9％、22．4％、10．9％、4．2％和1．7％。106例母婴血型不合且有ABO—HDN危险的孕妇所生新生儿中共有24例HDN阳性，占22，6％；孕妇JgG抗-A（B）效价为64、128、256和≥512各组HDN阳性率分别为12．0％、24．1％、38．1％和50．0％（P〈0．01）。结论孕妇血清中IgG抗-A（B）效价高低与ABO—HDN的发生率成正相关，产前进行血清IgG抗体效价检测非常必要。Objective To study the relationship between blood group antibody IgG titer of pregnant women and ABO hemolytic disease of newborn （HDN）. Methods Blood group antibody lgG titers of 716 pregnant women who were O and Rh positive with a non - O husband were detected. After born, blood groups, Coomb, s test, free antibody and antibody release test were done for those 106 babies who were in high risk of HDN. Results The percent of anti - A（B） IgG titer 〈64,64, 128,256 ands512 in the 716 O type pregnant women was 60. 9%, 22. 4%, 10. 9%, 4. 2% and 1.7%, respectively. There were 24 babies suffered from HDN in those 106 babies who had high risk, which accounted for 22.6%. With the anti - A （ B ）IEG titer was 64,128,256 and ≥ 512, the percent of H DN positive was 12. 0 % , 24. 1%, 38. 1% and 50. 0%, respectively （ P 〈 0. 01 ）. Conclusion There is a positive relationship between blood group antibody IgG titer of pregnant women and ABO -HDN. It is necessary for the pregnant women to detect the level of anti -A（B） IgG.

关 键 词：抗体效价 新生儿溶血病 抗-A(B) 

分 类 号：R722.18[医药卫生—儿科]