血浆CA125在不同妇科疾病中的表达水平及其对疗效的评估价值  

Serum level of CA125 in various gynecological diseases and its evaluative value on therapeutic effect

作　　者：范文勇[1] 

机构地区：[1]深圳市宝安区人民医院,广东深圳518101

出　　处：《中国当代医药》2011年第3期33-34,共2页China Modern Medicine

摘　　要：目的:探讨血浆Carcinoma antigen125(CA125)在不同妇科疾病的表达水平及其对疗效的评估价值。方法:收集82例妇科疾病患者,抽取空腹静脉血用于血浆CA125检测,采用免疫放射法重复检测3次,同时收集30例健康者作为对照,比较各组间血浆CA125水平。治疗6个月后,评估各组患者血浆CA125水平,同时行妇科CT检查评价各组患者复发或残留病灶例数。结果:妇科恶性肿瘤患者血浆CA125水平较良性病变组明显升高(P<0.05),其中卵巢癌升高最明显;治疗6个月后各组患者血浆CA125水平均有不同程度的下降;结合CT结果,各组复发或残留病灶患者血浆CA125水平均较无复发或残留病灶患者高。结论:血浆CA125在本研究不同妇科疾病患者中均有不同程度的升高,其中以卵巢癌患者升高最明显;治疗后各组患者血浆CA125水平均有不同程度的下降,其中血浆CA125水平仍较高者对诊断复发或残留病灶具有一定评估价值。Objective：To investigate serum level of CA125 in various gynecological diseases and the evaluative value of serum level of CA125 on therapeutic effect.Methods：cellected 82 patients with various gynecological diseases and drawn fasting serum used for CA125 detection triply by immunoradiometry.30 healthy subjects as control group.Serum level of CA125 was compared among groups.Six months after treatment,evaluated serum level of CA125 and concomitantly with gynecological CT to evaluate relapse or residual disease.Results：Serum level of CA125 was significant higher in malignant gynecological diseases than benign group（P0.05）.Serum level of CA125 was most prominent in ovarian cancer.Six months later,serum level of CA125 decreased in various degrees.In conjunction with CT results,serum level of CA125 was higher in patients with relapse or residual disease than those without relapse or residual disease.Conclusion：Serum level of CA125 increased in various gynecological diseases with various degrees and most prominent in ovarian cancer.Serum level of CA125 decreased in various degrees after treatment and higher level of serum CA125 has evaluative value on relapse or residual diseases diagnosis.

关 键 词：CA125 妇科疾病 评估价值 

分 类 号：R711[医药卫生—妇产科学]