偕二氟取代芳香仲醇拆分条件及其酯类对映体的高效液相色谱法分离  

Separation of some chiral α-difluoromethyl aryl alcohols and their esters enantiomers by HPLC

作　　者：张瑾 颜超[2] 谢永力[2] 徐青[2] 陈沛然[2] 

机构地区：[1]上海市城市排水监测站,上海200062 [2]东华大学化学化工与生物工程学院,上海201620

出　　处：《分析试验室》2011年第2期14-17,共4页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金项目(20602007)资助

摘　　要：利用正相高效液相色谱法在一种纤维素衍生物手性固定相(OJ-H或OD-H)上成功分离了一系列α位偕二氟取代的芳香醇及其酯化后的对映异构体。通过考察流动相组成、流速、进样浓度和温度等因素对对映体分离的影响,优化色谱分离条件。Some enantiomers α-difluoromethyl aryl alcohols and their esters were successfully separated by a cellulose derivative based chiral stationary phase （OJ-H or OD-H）under normal-phase high performance liquid chromatographic （HPLC） conditions. The influence of the composition of mobile phase, the flow rate, the injected concentration on the enantiomer rentention and selectivity and effect of column temperature on the chiral separation were investigated, and the chromatographic conditions were optimized.

关 键 词：高效液相色谱 手性固定相 手性拆分 含氟芳香仲醇 

分 类 号：O657.7[理学—分析化学]